Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions.
Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions.
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DOI：
10.3389/fimmu.2018.00255
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发表时间：
2018
影响因子：
7.3
通讯作者：
Pitt D
中科院分区：
文献类型：
--
作者：
Gillen KM;Mubarak M;Nguyen TD;Pitt D
小胶质细胞是在中枢神经系统（CNS）中发挥保护和自我平衡功能的常驻免疫细胞，但也可能促进老年大脑和慢性疾病的神经毒性。多发性硬化症（MS）是一种中枢神经系统自身免疫性脱髓鞘疾病，小胶质细胞和巨噬细胞通过髓磷脂吞噬作用促进白质病变的发展，并可能通过髓质白质的弥漫性激活促进疾病进展。在这篇综述中，我们讨论了多发性硬化症中骨髓细胞活化的另一个区室，即慢性活动性病变的边缘和正常邻近白质。在慢性活动性病变中，小胶质细胞和巨噬细胞可能含有大量的铁，表达促炎极化标记物，激活时间延长（数年），并导致慢性组织损伤。铁阳性骨髓细胞可以通过定量敏感性作图（QSM），一种磁共振成像技术进行可视化和定量。因此，QSM有潜力作为白质MS病变慢性炎症活性的体内生物标志物。使用现有或新的MS疗法减少与铁积累相关的慢性炎症可能会影响疾病的严重程度和进展。
Microglia are resident immune cells that fulfill protective and homeostatic functions in the central nervous system (CNS) but may also promote neurotoxicity in the aged brain and in chronic disease. In multiple sclerosis (MS), an autoimmune demyelinating disease of the CNS, microglia and macrophages contribute to the development of white matter lesions through myelin phagocytosis, and possibly to disease progression through diffuse activation throughout myelinated white matter. In this review, we discuss an additional compartment of myeloid cell activation in MS, i.e., the rim and normal adjacent white matter of chronic active lesions. In chronic active lesions, microglia and macrophages may contain high amounts of iron, express markers of proinflammatory polarization, are activated for an extended period of time (years), and drive chronic tissue damage. Iron-positive myeloid cells can be visualized and quantified with quantitative susceptibility mapping (QSM), a magnetic resonance imaging technique. Thus, QSM has potential as an in vivo biomarker for chronic inflammatory activity in established white matter MS lesions. Reducing chronic inflammation associated with iron accumulation using existing or novel MS therapies may impact disease severity and progression.
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DOI：
10.1002/mds.26417
发表时间：
2016-03
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Du G;Liu T;Lewis MM;Kong L;Wang Y;Connor J;Mailman RB;Huang X
通讯作者：
Huang X
ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4.2
作者：
CONNOR, JR;MENZIES, SL;MUFSON, EJ
通讯作者：
MUFSON, EJ
影响因子：
3.6
作者：
Beaumont, Carole;Delaby, Constance
通讯作者：
Delaby, Constance