Roles of circRNAs in hematological malignancies.
Roles of circRNAs in hematological malignancies.
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Circrnas在血液学恶性肿瘤中的作用。
DOI：
10.1186/s40364-022-00392-2
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发表时间：
2022-07-15
影响因子：
11.1
通讯作者：
Wei, Sixi
中科院分区：
文献类型：
--
作者：
Deng, Fahua;Zhang, Chengsi;Lu, Tingting;Liao, Ezhong Joshua;Huang, Hai;Wei, Sixi
恶性血液病是导致死亡的主要原因之一，其发病率不断上升，耐药性和治疗后患者的复发是临床挑战。因此，迫切需要发现生物标志物，以指示血液系统恶性肿瘤的发展，进展和治疗靶点。环状RNA（circRNA）是共价闭合的环状单链RNA，其生物合成受多种因素调节，在许多生物体中广泛表达且进化保守，并以组织/细胞特异性方式表达。最近的报告表明，circRNA在血液恶性肿瘤的进展中起着重要作用。然而，使用常规技术难以检测低丰度的circRNA。我们需要了解更多关于它们的特征的信息，以开发新的检测方法。本文就circRNA的特性及其在血液系统恶性肿瘤中的研究进展进行综述，并探讨其可能的研究方向。
As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic malignancies. Circular RNAs (circRNAs) are covalently closed circular-single-stranded RNAs whose biosynthesis is regulated by various factors and is widely-expressed and evolutionarily conserved in many organisms and expressed in a tissue−/cell-specific manner. Recent reports have indicated that circRNAs plays an essential role in the progression of hematological malignancies. However, circRNAs are difficult to detect with low abundance using conventional techniques. We need to learn more information about their features to develop new detection methods. Herein, we sought to retrospect the current knowledge about the characteristics of circRNAs and summarized research on circRNAs in hematological malignancies to explore a potential direction.
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