Phosphene-guided transcranial magnetic stimulation of occipital but not parietal cortex suppresses stimulus visibility.

Phosphene-guided transcranial magnetic stimulation of occipital but not parietal cortex suppresses stimulus visibility.
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DOI:
10.1007/s00221-014-3888-y
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发表时间:
2014-06
影响因子:
2
通讯作者:
Beck, Diane M.
Beck, Diane M.
中科院分区:
医学4区
文献类型:
--
作者:
Tapia, Evelina;Mazzi, Chiara;Savazzi, Silvia;Beck, Diane M.

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经颅磁刺激(TMS)在刺激开始约100毫秒后应用于枕叶,如果刺激出现在磷光脑的位置,则会降低其可见性。由于刺激顶叶区域也能引起光幻视,我们想知道,当颅磁刺激应用于顶叶区域时,用于降低刺激可见性的相同程序是否会导致刺激可见性降低。在刺激开始后0 ~ 130 ms随机应用经颅磁刺激(TMS),每10 ms在枕区和顶叶区进行。参与者对线刺激的方向作出反应,并评价其可见性。我们重复以前的报道,从枕部和顶叶经颅磁刺激中发现磷光幻视。正如之前报道的那样,我们还观察到枕部经颅磁刺激在经典100 ms窗口周围的客观线取向和主观可见性反应中存在视觉抑制。另一方面,顶叶刺激并没有在任何时间窗口内持续降低刺激的可见性。
Transcranial magnetic stimulation (TMS) applied over the occipital lobe approximately 100 ms after the onset of a stimulus decreases its visibility if it appears in the location of the phosphene. Because phosphenes can also be elicited by stimulation of the parietal regions, we asked if the same procedure that is used to reduce visibility of stimuli with occipital TMS will lead to decreased stimulus visibility when TMS is applied to parietal regions. TMS was randomly applied at 0 to 130 ms after the onset of the stimulus (SOA) in steps of 10 ms in occipital and parietal regions. Participants responded to the orientation of the line stimulus and rated its visibility. We replicate previous reports of phosphenes from both occipital and parietal TMS. As previously reported, we also observed visual suppression around the classical 100 ms window both in the objective line orientation and subjective visibility responses with occipital TMS. Parietal stimulation, on the other hand, did not consistently reduce stimulus visibility in any time window.
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