Efficacy of an intervention for fatigue and sleep disturbance during cancer chemotherapy.
Efficacy of an intervention for fatigue and sleep disturbance during cancer chemotherapy.
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DOI：
10.1016/j.jpainsymman.2009.12.020
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发表时间：
2010-08
影响因子：
4.7
通讯作者：
Stewart, Katie
中科院分区：
文献类型：
--
作者：
Barsevick, Andrea;Beck, Susan L.;Dudley, William N.;Wong, Bob;Berger, Ann M.;Whitmer, Kyra;Newhall, Tracey;Brown, Susan;Stewart, Katie
关键词：
癌症治疗产生的多种复杂症状可能会干扰功能。评估“能量和睡眠增强”（EASE）干预措施在缓解疲劳和睡眠障碍以及改善健康相关功能状态方面的功效。接受化疗的个体被随机分配至 EASE (n = 153) 或对照干预组 (n = 139)。 EASE 干预包括肿瘤科护士在三个电话会议中教授的信息和行为技能。疲劳、睡眠障碍和功能状态等主要结局在化疗前、首次治疗后第 4 天（基线）以及 43-46 或 57-60 天后（随访）进行测量，具体取决于化疗周期的长度。样本主要是女性 (82%) 和非西班牙裔白人 (89%)，平均年龄为 53.9 岁。在基线和随访时，两组的疲劳和患者报告的睡眠障碍均有所增加。体动记录仪显示，两组在两个时间点的总睡眠时间接近八小时，睡眠百分比均超过 85%（正常范围）。身体机能下降，与患有严重疾病的样本处于同一水平。心理功能处于正常范围。重复测量方差分析显示，对于疲劳、睡眠障碍或功能状态，按时间分组没有显着的统计学影响。失业者从 EASE 干预中获益更大，报告疼痛和症状干扰更少。可能的解释包括疲劳的高变异性和/或地板效应；措施时机不正确；干预措施的量或剂量不足；以及性别的混杂影响。未来的研究应考虑筛查症状严重程度并制定干预措施。
Multiple complex symptoms from cancer treatment can interfere with functioning. To evaluate the efficacy of an “energy and sleep enhancement” (EASE) intervention to relieve fatigue and sleep disturbance and improve health-related functional status. Individuals receiving chemotherapy were randomized to the EASE (n = 153) or a control intervention (n = 139). The EASE intervention included information and behavioral skills taught by an oncology nurse in three telephone sessions. The primary outcomes of fatigue, sleep disturbance and functional status were measured before chemotherapy, Day 4 after first treatment (baseline) and 43-46 or 57-60 days later (follow-up) depending on chemotherapy cycle length. The sample was primarily female (82%) and non-Hispanic white (89%) with mean age of 53.9 years. Fatigue and patient-reported sleep disturbance were elevated in both groups at baseline and follow-up. Actigraphy revealed total sleep time was almost eight hours and sleep percent was over 85% for both groups at both time points (normal range). Physical functioning was diminished and at the same level as a sample with serious illness. Mental functioning was in normal range. A repeated measures analysis of variance revealed no statistically significant group-by-time effects for fatigue, sleep disturbance, or functional status. Unemployed individuals showed greater benefit from the EASE intervention, reporting less pain and symptom interference. Potential explanations include high variability and/or floor effect for fatigue; incorrect timing of measures; insufficient amount or dose of the intervention; and confounding effects of gender. Future research should consider screening for symptom severity and tailoring interventions.
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影响因子：
4.7
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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