Construction of cardiac tissue rings using a magnetic tissue fabrication technique.
Construction of cardiac tissue rings using a magnetic tissue fabrication technique.
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DOI:
10.3390/ijms11082910
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发表时间:
2010-08-10
影响因子:
5.6
通讯作者:
Kamihira M
中科院分区:
文献类型:
--
作者:
Akiyama H;Ito A;Sato M;Kawabe Y;Kamihira M
Here we applied a magnetic force-based tissue engineering technique to cardiac tissue fabrication. A mixture of extracellular matrix precursor and cardiomyocytes labeled with magnetic nanoparticles was added into a well containing a central polycarbonate cylinder. With the use of a magnet, the cells were attracted to the bottom of the well and allowed to form a cell layer. During cultivation, the cell layer shrank towards the cylinder, leading to the formation of a ring-shaped tissue that possessed a multilayered cell structure and contractile properties. These results indicate that magnetic tissue fabrication is a promising approach for cardiac tissue engineering.
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通讯作者:
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