Tuberculosis susceptibility and protection in children.
Tuberculosis susceptibility and protection in children.
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DOI：
10.1016/s1473-3099(18)30157-9
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Kampmann B
中科院分区：
文献类型：
--
作者：
Basu Roy R;Whittaker E;Seddon JA;Kampmann B
儿童既是临床重要的结核病易感人群，也是研究内在和疫苗诱导的保护机制的关键群体。幼儿在接触结核分枝杆菌后，首先发展为结核感染，然后发展为结核病，并可能发展为播散性结核病的高风险，并伴有高发病率和死亡率。年龄较小的学龄儿童相对受到保护，在青春期风险再次增加之前。此外，儿童是唯一证明卡介苗免疫有益的群体。来自关键队列的病例对照比较，其中招募了15,000多名儿童和年轻人，已经确定单核细胞：淋巴细胞比例，活化的CD4 T细胞和RNA标记是发生结核病风险的相关因素。有必要对受保护人群和易感人群进行进一步研究，以指导新型结核病疫苗的开发，从而促进实现儿童结核病零死亡的目标。
Children represent both a clinically important population susceptible to tuberculosis, but also a key group in whom to study intrinsic and vaccine-induced mechanisms of protection. Following exposure to Mycobacterium tuberculosis, young children are at high risk of progressing first to tuberculosis infection, then tuberculosis disease and possibly disseminated forms of tuberculosis, with accompanying high morbidity and mortality. Younger school-age children are relatively protected, before risk increases again in adolescence. Furthermore, children are the only group for whom there is proven benefit of Bacillus Calmette-Guérin (BCG) immunization. Case-control comparisons from key cohorts, which recruited more than 15,000 children and young people between them, have identified the monocyte:lymphocyte ratio, activated CD4 T cells, and an RNA signature as correlates of risk for developing tuberculosis. Further studies of protected and susceptible populations are necessary to guide development of novel tuberculosis vaccines that could facilitate the goal of zero childhood tuberculosis deaths.
影响因子：
3.7
作者：
Portevin D;Moukambi F;Mpina M;Bauer A;Haraka F;Chachage M;Metzger P;Saathoff E;Clowes P;Ntinginya NE;Rachow A;Hoelscher M;Reither K;Daubenberger CA;Geldmacher C
通讯作者：
Geldmacher C