Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium tuberculosis Co-Infections.
Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium tuberculosis Co-Infections.
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DOI：
10.1371/journal.pone.0126716
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Geldmacher C
中科院分区：
文献类型：
--
作者：
Portevin D;Moukambi F;Mpina M;Bauer A;Haraka F;Chachage M;Metzger P;Saathoff E;Clowes P;Ntinginya NE;Rachow A;Hoelscher M;Reither K;Daubenberger CA;Geldmacher C
人们普遍认为，衰老和HIV感染与CMV特异性T细胞应答的数量和功能变化有关。我们在这里研究了一组坦桑尼亚志愿者(16岁的≤和18岁的≥，n=79)中巨噬细胞炎性蛋白-1和T细胞成熟标记CD27的表达与年龄、艾滋病毒和活动性结核病(TB)合并感染的关系。与艾滋病毒合并感染无关，干扰素γ+CMVpp65特异性CD4+T细胞频率随着年龄的增长而增加。在成年人中，艾滋病毒合并感染进一步增加了这些细胞的频率。在儿童和成人中，这些细胞具有高表达MIP-1β的能力和CD27低表型。有趣的是，除了艾滋病毒合并感染外，活动性结核病还与CD27的进一步下调和CMVpp65特异性β+T细胞中MIP-1CD4+T细胞产生能力的增加有关。在HIV感染和活动性结核病期间观察到的CMVpp65特异性CD4T细胞的这些表型和功能变化可能与CMV重新激活率的增加有关。
It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4+ and CD8+ T cells in relation to age, HIV and active Tuberculosis (TB) co-infection in a cohort of Tanzanian volunteers (≤16 years of age, n = 108 and ≥18 years, n = 79). Independent of HIV co-infection, IFNγ+ CMVpp65-specific CD4+ T cell frequencies increased with age. In adults, HIV co-infection further increased the frequencies of these cells. A high capacity for Mip-1β production together with a CD27low phenotype was characteristic for these cells in children and adults. Interestingly, in addition to HIV co-infection active TB disease was linked to further down regulation of CD27 and increased capacity of Mip-1β production in CMVpp65-specific CD4+ T cells. These phenotypic and functional changes of CMVpp65-specific CD4 T cells observed during HIV infection and active TB could be associated with increased CMV reactivation rates.
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