Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria.
Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria.
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DOI：
10.1016/j.celrep.2021.109956
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发表时间：
2021-11-02
期刊：
影响因子：
8.8
通讯作者：
Harty JT
中科院分区：
文献类型：
--
作者：
Lefebvre MN;Surette FA;Anthony SM;Vijay R;Jensen IJ;Pewe LL;Hancox LS;Van Braeckel-Budimir N;van de Wall S;Urban SL;Mix MR;Kurup SP;Badovinac VP;Butler NS;Harty JT
肝期疟疾感染期间循环记忆 CD8 T 细胞的运输和保护能力仍不清楚。我们发现效应记忆 CD8 T 细胞 (Tem) 在疟疾或细菌感染后 6 小时内浸润肝脏并介导病原体清除。 Tem 的招募与疟原虫感染的肝脏中炎症基因的快速转录上调同时发生。招募需要 CD8 T 细胞固有的 LFA-1 表达和肝脏吞噬细胞的存在。快速 Tem 肝脏浸润与向其他非淋巴组织的募集不同，因为它发生在肝组织常驻记忆“感知和警报”功能不存在的情况下，并且比流感病毒肺部感染早约 42 小时。这些数据证明了 Tem 在预防疟疾方面的相关性，并提供了与控制肝脏感染密切相关的普遍机制见解。列斐伏尔等人。描述循环记忆 CD8 T 细胞浸润肝脏以控制局部疟疾和细菌感染的动力学和机制。这项工作表明，循环记忆 CD8 T 细胞可能成为开发疟疾和其他肝脏特异性病原体疫苗和疗法的有用靶标。
Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory “sensing-and-alarm” function and ~42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights germane to control of liver infections. Lefebvre et al. describe the dynamics and mechanisms by which circulating memory CD8 T cells infiltrate the liver to control local malaria and bacterial infection. This work suggests that circulating memory CD8 T cells could be useful targets for developing vaccines and therapeutics for malaria and other liver-specific pathogens.
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影响因子：
82.9
作者：
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通讯作者：
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DOI：
10.1073/pnas.1303858110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Cockburn, Ian A.;Amino, Rogerio;Menard, Robert
通讯作者：
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