Risk of secondary malignant neoplasms from proton therapy and intensity-modulated x-ray therapy for early-stage prostate cancer.
Risk of secondary malignant neoplasms from proton therapy and intensity-modulated x-ray therapy for early-stage prostate cancer.
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DOI：
10.1016/j.ijrobp.2009.01.001
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发表时间：
2009-06-01
影响因子：
7
通讯作者：
Newhauser, Wayne D.
中科院分区：
文献类型：
--
作者：
Fontenot, Jonas D.;Lee, Andrew K.;Newhauser, Wayne D.
评估质子治疗相对于使用 X 射线的调强放射治疗 (IMRT) 引起继发性恶性肿瘤 (SMN) 的风险，同时考虑主要和次要放射源对前列腺癌的影响。为 3 名早期前列腺腺癌患者制定了质子治疗计划和 6-MV IMRT 计划。从主要场输送到有发生 SMN 风险的器官的剂量是根据治疗计划确定的。质子治疗和 IMRT 的二次剂量分别根据蒙特卡罗模拟和可用的测量数据确定。 SMN 的风险是通过使用电离辐射生物效应委员会的风险模型，根据逐个器官的初级和次级剂量来估计的。与 IMRT 相比，质子治疗可将 SMN 风险降低 26% 至 39%。两种方式的 SMN 风险在现场器官中最大。然而，质子治疗计划的现场器官风险比 IMRT 计划低得多。这种减少归因于质子治疗计划使直肠和膀胱基本上免于暴露于治疗束。当考虑暴露于初次和二次放射时，与当代 IMRT 相比，质子治疗可以降低前列腺患者发生 SMN 的风险。
To assess the risk of a secondary malignant neoplasm (SMN) from proton therapy relative to intensity-modulated radiation therapy (IMRT) using X-rays, taking into account contributions from both primary and secondary sources of radiation, for prostate cancer. A proton therapy plan and a 6-MV IMRT plan were constructed for 3 patients with early-stage adenocarcinoma of the prostate. Doses from the primary fields delivered to organs at risk of developing an SMN were determined from treatment plans. Secondary doses from the proton therapy and IMRT were determined from Monte Carlo simulations and available measured data, respectively. The risk of an SMN was estimated from primary and secondary doses on an organ-by-organ basis by use of risk models from the Committee on the Biological Effects of Ionizing Radiation. Proton therapy reduced the risk of an SMN by 26% to 39% compared with IMRT. The risk of an SMN for both modalities was greatest in the in-field organs. However, the risks from the in-field organs were considerably lower with the proton therapy plan than with the IMRT plan. This reduction was attributed to the substantial sparing of the rectum and bladder from exposure to the therapeutic beam by the proton therapy plan. When considering exposure to primary and secondary radiation, proton therapy can reduce the risk of an SMN in prostate patients compared with contemporary IMRT.
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影响因子：
2.2
作者：
Kellerer, Albrecht M.;Ruehm, Werner;Walsh, Linda
通讯作者：
Walsh, Linda
影响因子：
3.5
作者：
Taddei, Phillip J.;Fontenot, Jonas D.;Newhauser, Wayne D.
通讯作者：
Newhauser, Wayne D.
DOI：
10.1016/j.ijrobp.2007.02.029
发表时间：
2007-07-01
影响因子：
7
作者：
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通讯作者：
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影响因子：
29.4
作者：
Baxter, NN;Tepper, JE;Virnig, BA
通讯作者：
Virnig, BA
DOI：
10.1016/s0360-3016(03)01452-4
发表时间：
2004-01-01
影响因子：
7
作者：
Mock, U;Georg, D;Pötter, R
通讯作者：
Pötter, R