Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI.
Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI.
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DOI：
10.1002/mrm.21994
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发表时间：
2009-07
影响因子：
3.3
通讯作者：
Lu, Hanzhang
中科院分区：
文献类型：
--
作者：
Xu, Feng;Ge, Yulin;Lu, Hanzhang
关键词：
脑氧代谢率（CMRO 2）是反映脑功能和脑健康的重要指标。用正电子发射断层扫描（PET）或MRI定量CMRO 2的现有技术涉及特殊设备和/或外源性试剂，可能不适合常规临床研究。在本研究中，开发了一种非侵入性方法来估计人类全脑CMRO 2。该方法应用相衬MRI进行定量血流测量，T2-自旋标记下弛豫（TRUST）MRI进行静脉氧合估计，并使用动静脉差异的Fick原理计算CMRO 2。年轻健康受试者的全脑平均CMRO 2值为132.1±20.0 μmol/100 g/min，与使用PET的文献报告一致。比较了相位对比和TRUST MRI的各种采集策略，发现非门控相位对比和矢状窦TRUST MRI能够提供最有效和准确的CMRO 2估计。此外，发现受试者之间的血流量和静脉氧合呈正相关。由于这种方法的非侵入性，它可能是一种方便和有用的方法，用于评估脑代谢疾病以及在各种生理条件下。
Cerebral metabolic rate of oxygen (CMRO2) is an important marker for brain function and brain health. Existing techniques for quantification of CMRO2 with Positron Emission Tomography (PET) or MRI involve special equipment and/or exogenous agent, and may not be suitable for routine clinical studies. In the present study, a non-invasive method is developed to estimate whole-brain CMRO2 in humans. This method applies phase-contrast MRI for quantitative blood flow measurement and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI for venous oxygenation estimation, and uses the Fick principle of arteriovenous difference for the calculation of CMRO2. Whole-brain averaged CMRO2 values in young, healthy subjects were 132.1±20.0 μmol/100g/min, in good agreement with literature reports using PET. Various acquisition strategies for phase-contrast and TRUST MRI were compared, and it was found that non-gated phase-contrast and sagittal sinus TRUST MRI were able to provide the most efficient and accurate estimation of CMRO2. In addition, blood flow and venous oxygenation were found to be positively correlated across subjects. Owing to the non-invasive nature of this method, it may be a convenient and useful approach for assessment of brain metabolism in brain disorders as well as under various physiologic conditions.
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作者：
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通讯作者：
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DOI：
10.1073/pnas.83.4.1140
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