Studies on prostaglandin metabolism in corpora lutea of rabbits during pregnancy and pseudopregnancy.
Studies on prostaglandin metabolism in corpora lutea of rabbits during pregnancy and pseudopregnancy.
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孕期和假孕期家兔黄体前列腺素代谢的研究。
DOI：
10.1530/jrf.0.0830365
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
H. M. Beier
中科院分区：
文献类型：
--
作者：
W. Schlegel;S. Krüger;D. Daniels;B. Fischer;H. Schneider;H. M. Beier
在诱导排卵后8、10、12、13和15天，分析黄体和卵巢间质组织中前列腺素（PG）的浓度和参与PG代谢的酶的活性。在假孕兔CL中，与第8天相比，第10、12和15天的PGE-2 -9-酮还原酶（PGE-2-9-KR）活性较高（P <0.01; P <0.001; P <0.05）。在妊娠动物中，PGE-2-9-KR活性仅在第12天增加（P小于0.05），但在第13天和第15天下降至基础水平。比较假孕和妊娠动物的PGE-2-9-KR活性，发现假孕第15天显著升高（P <0.025）。PG-15-羟脱氢酶活性在假孕或妊娠兔中未表现出任何显著的随时间的变化。与第8天相比，第12、13和15天的PGE-2浓度升高（P <0.025）。PGF-2 α浓度的变化与PGE-2-9-KR的变化一致。PG代谢物13，14-二氢-15-酮-PGE-2和-PGF-2 α的浓度低于主要PG的浓度，并且在假孕和妊娠动物中未显示阶段特异性变化。这些结果表明，兔CL具有将PGE-2转化为PGF-2 α并代谢两种PG的酶。PGE-2-9-KR可能参与调节PGF-2 α/PGE-2比值，并可能参与控制黄体的寿命。
Corpora lutea and ovarian stromal tissue were analysed for prostaglandin (PG) concentrations and activities of enzymes involved in PG metabolism at 8, 10, 12, 13 and 15 days after induction of ovulation. In CL of pseudopregnant rabbits, the PGE-2-9-ketoreductase (PGE-2-9-KR) was highly active on Days 10, 12 and 15 when compared with Day 8 (P less than 0.01; P less than 0.001; P less than 0.05). In pregnant animals PGE-2-9-KR activity was only increased on Day 12 (P less than 0.05) but declined to basal levels on Days 13 and 15. Comparing PGE-2-9-KR activity of pseudopregnant and pregnant animals, a significant elevation was found on Day 15 of pseudopregnancy (P less than 0.025). Activities of PG-15-hydroxydehydrogenase did not exhibit any significant changes with time in pseudopregnant or pregnant rabbits. PGE-2 concentrations were increased on Days 12, 13 and 15 (P less than 0.025) when compared with Day 8. Changes in PGF-2 alpha concentrations paralleled those of PGE-2-9-KR. The concentrations of PG metabolites 13,14-dihydro-15-keto-PGE-2 and -PGF-2 alpha were lower than those of the primary PGs and did not show stage-specific changes in pseudopregnant and pregnant animals. These results demonstrate that the rabbit CL possesses enzymes to convert PGE-2 to PGF-2 alpha and to metabolize both PGs. PGE-2-9-KR may be involved in regulating the PGF-2 alpha/PGE-2 ratio and possibly in controlling the life-span of the corpus luteum.
黄体退化过程中兔子血浆和组织前列腺素水平的变化。
影响因子：
3.6
作者：
Miller,JB;Jarosik,C;Stanisic,D;WilsonJr,L
通讯作者：
WilsonJr,L
前列腺素 F2 α 对卵巢和黄体血流、体内黄体促性腺激素摄取和体外促性腺激素结合的急性影响。
影响因子：
4.8
作者：
Pang,CY;Behrman,HR
通讯作者：
Behrman,HR