Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression.
Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression.
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黄体退化过程中兔子血浆和组织前列腺素水平的变化。
DOI：
10.1095/biolreprod29.4.824
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发表时间：
1983
影响因子：
3.6
通讯作者：
WilsonJr,L
中科院分区：
文献类型：
--
作者：
Miller,JB;Jarosik,C;Stanisic,D;WilsonJr,L
为了确定卵巢和子宫前列腺素的产生是否与黄体退化有关，组织和血浆中前列腺素F（PGF）、前列腺素E（PGE）、6-酮-PGF 1 α（6-keto-PGF 1 α）在第8天通过放射免疫法测定子宫、黄体、非黄体组织、子宫静脉血浆和卵巢静脉血浆中的6-酮-PGF和血栓素B2（TxB），12和15的假孕激素。总前列腺素水平（PGF + PGE + 6-keto-PGF + TxB）在子宫中比非黄体组织高4倍，比黄体高8倍。第15天子宫组织中PGF和PGE水平均较第8天和第12天升高（P<0.01）。与第8或12天相比，第15天PGF：PGE的比率也升高（P<0.05），这表明PGF的溶黄体作用优于PGE可能的促黄体作用。子宫组织中TxB和6-keto-PGF的浓度及TxB/6-keto-PGF的比值在研究的任何一天均无显著变化。在非黄体组织中，PGE是唯一显著变化的PG;与第12或15天相比，PGE水平在假孕第8天升高（P<0.05）。虽然黄体含有大量的PGF、PGE、TxB和6-酮-PGF，但在假孕第8、12或15天之间未观察到任何这些物质的水平发生变化。此外，卵巢静脉血浆中任何PG的水平或黄体和非黄体组织或卵巢静脉血浆中PGF：PGE或TxB：6-keto-PGF的比率均无显著变化。总之，在家兔中观察到随着黄体退化而增加的唯一PG是子宫组织中的PGF。这些数据并不支持在家兔假孕过程中黄体内产生PGF、PGE、TxB或6-keto-PGF在调节黄体功能中起主要作用的观点。
To determine if ovarian as well as uterine prostaglandin production was associated with luteal regression, tissue and plasma concentrations of prostaglandin F (PGF), prostaglandin E (PGE), 6-keto-PGF1 α(6-keto-PGF), and thromboxane B2(TxB) were measured by radioimmunoassay in uterus, corpora lutea, nonluteal tissue, uterine venous plasma and ovarian venous plasma on Days 8, 12 and 15 of pseudopregnancy in the rabbit. Total prostaglandin levels (PGF + PGE + 6-keto-PGF + TxB) were 4-fold greater in the uterus compared to nonluteal tissue and 8-fold greater than in corpora lutea. Both PGF and PGE levels were increased in uterine tissue on Day 15 compared to Days 8 or 12 (P<0.01). The ratio of PGF:PGE was also elevated on Day 15 compared to Days 8 or 12 (P<0.05) which suggests that the luteolytic effect of PGF predominates over the possible luteotropic effect of PGE. There were no significant changes in the concentration of TxB or 6-keto-PGF or the ratio of TxB:6-keto-PGF in uterine tissue on any day studied. In nonluteal tissue, PGE was the only PG to vary significantly; PGE levels were elevated (P<0.05) on Day 8 of pseudopregnancy compared to Days 12 or 15. Although corpora lutea contain significant quantities of PGF, PGE, TxB and 6-keto-PGF, no alterations in the levels of any of these substances were observed between Days 8, 12 or 15 of pseudopregnancy. In addition, there were no significant alterations in the levels of any PG in ovarian venous plasma or in the ratio of either PGF:PGE or TxB:6-keto-PGF in luteal and nonluteal tissue or the ovarian venous plasma. In summary, the only PG which was observed to increase with luteal regression in the rabbit was PGF in uterine tissue. These data do not support the concept that intraluteal production of PGF, PGE, TxB or 6-keto-PGF plays a predominant role in regulating luteal function during pseudopregnancy in the rabbit.
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6-酮前列腺素 F1α 的灵敏放射免疫测定法：循环浓度的初步观察。
DOI：
--
发表时间：
1978
期刊：
Prostaglandins and Medicine
影响因子：
--
作者：
Murray D. Mitchell
通讯作者：
Murray D. Mitchell
同时使用两种前列腺素放射免疫测定法，采用两种不同特异性的抗血清。
DOI：
10.1016/0090-6980(76)90060-5
发表时间：
1976
期刊：
Prostaglandins
影响因子：
--
作者：
E. Ritzi;W. Stylos
通讯作者：
W. Stylos
同时使用两种前列腺素 E 放射免疫测定法，采用两种不同特异性的抗血清。
DOI：
10.1016/0090-6980(74)90037-9
发表时间：
1974
期刊：
Prostaglandins
影响因子：
--
作者：
E. Ritzi;W. Stylos
通讯作者：
W. Stylos
罗斯塔兰素在生殖中的作用。
影响因子：
33.6
作者：
V. Goldberg;P. Ramwell
通讯作者：
P. Ramwell
前列腺素 F2α 对兔卵巢血流的重新分配
影响因子：
9.8
作者：
M. Novy;M. J. Cook
通讯作者：
M. J. Cook