Vertebral fracture assessment in adolescents and young women with anorexia nervosa: a case series.
Vertebral fracture assessment in adolescents and young women with anorexia nervosa: a case series.
复制标题
DOI：
10.1016/j.jocd.2013.02.011
复制
发表时间：
2014-01
影响因子：
2.5
通讯作者：
Gordon, Catherine M.
中科院分区：
文献类型：
--
作者：
DiVasta, Amy D.;Feldman, Henry A.;Gordon, Catherine M.
年轻女性神经性厌食症（AN）的椎骨骨折（VF）发生率尚不清楚。我们试图确定AN患者的无症状VF发生率，假设低BMD Z评分的受试者VF发生率较高。我们招募了年轻女性AN（n=80）参与纵向试验。在0、6、12和18个月时获得侧胸和腰椎的双能X线吸收测量图像，用于椎体骨折评估。13例受试者（16%）基线时脊柱BMD较低（BMD Z评分≤ -2 SD）。使用Genant半定量技术，基线时2/80例受试者（2.5%）有单一Genant 1级畸形的证据。1例受试者发生Genant 2级畸形。在为期18个月的试验中，9例受试者（12.5%）发生了10起椎骨骨折事件。使用定量技术，只有两名受试者的椎体高度损失>15%。人体测量数据和疾病严重程度的标志物都与骨折无关。总之，在我们的队列中，患有AN的年轻女性无症状VF的风险较低。患病时间、营养不良的严重程度或腰椎aBMD的传统测量方法不能预测椎体骨折。
Rates of vertebral fracture (VF) for young women with anorexia nervosa (AN) are not well understood. We sought to determine the rates of asymptomatic VF in patients suffering from AN, hypothesizing that VF rates would be higher in subjects with low BMD Z-scores. We recruited young women with AN (n=80) for participation in a longitudinal trial. Dual-energy X-ray absorptiometry images of the lateral thoracic and lumbar spine were obtained for vertebral fracture assessment at 0, 6, 12, and 18 months. Thirteen subjects (16%) had a low spinal BMD at baseline (BMD Z-score ≤ –2 SD). Using the Genant semiquantitative technique, 2/80 subjects at baseline (2.5%) had evidence of a single, Genant grade 1 deformity. One subject had a Genant Grade 2 deformity. Over the 18-month trial, 10 incident vertebral fractures occurred in 9 subjects (12.5%). Using quantitative techniques, only two subjects had a >15% loss in vertebral height. Neither anthropometric data nor markers of disease severity were associated with fracture. In conclusion, ill young women with AN were at low risk for asymptomatic VF in our cohort. Vertebral fractures were not predicted by duration of illness, severity of malnutrition, or traditional measures of aBMD at the lumbar spine.
登录
查看更多内容
影响因子：
4.1
作者：
Mayranpaa, Mervi K.;Helenius, Ilkka;Makitie, Outi
通讯作者：
Makitie, Outi
影响因子：
5.1
作者：
Nakhla, Meranda;Scuccimarri, Rosie;Rodd, Celia
通讯作者：
Rodd, Celia
影响因子：
4
作者：
LOOKER, AC;WAHNER, HW;LINDSAY, RL
通讯作者：
LINDSAY, RL
影响因子：
120.7
作者：
Cauley, Jane A.;Hochberg, Marc C.;Cummings, Steven R.
通讯作者：
Cummings, Steven R.
影响因子：
120.7
作者：
RIGOTTI, NA;NEER, RM;NUSSBAUM, SR
通讯作者：
NUSSBAUM, SR