Secondary absorbed doses from light ion irradiation in anthropomorphic phantoms representing an adult male and a 10 year old child
Secondary absorbed doses from light ion irradiation in anthropomorphic phantoms representing an adult male and a 10 year old child
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代表成年男性和 10 岁儿童的拟人模型中光离子照射的二次吸收剂量
DOI：
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发表时间：
2010
影响因子：
3.5
通讯作者：
I. Gudowska
中科院分区：
文献类型：
--
作者：
Martha Hultqvist;I. Gudowska
次级器官吸收剂量通过蒙特卡洛模拟计算，使用SHIELD-HIT 07代码以及数学拟人模型CHILD-HIT和ADAM-HIT。模拟辐照是用能量范围为100-400 MeV/u的1H、4 He、7 Li、12 C和16 O初级离子束进行的，这些离子束直接撞击在体模上，即近似扫描束，并且用简化的束线进行12 C辐照。评价的野外器官吸收剂量范围为10−6至10−1 m戈伊/靶戈伊，标准差为0.5- 20%。虽然在低原子序数Z的离子束中，次级中子对器官吸收剂量的贡献占主导地位，但随着初级离子Z的增加，产生的带电碎片及其随后的高世代带电次级碎片对次级剂量输送变得越来越重要。与模拟扫描的12 C离子束相比，使用12 C离子进行前列腺照射的简化束线的实施导致器官吸收剂量增加2-50倍，这取决于与靶体积的距离。当考虑局部肿瘤控制离子的RBE并对靶点的RBE加权剂量进行归一化时，1H和12 C射束所提供的次级器官吸收剂量的比较显示出较小的差异。
Secondary organ absorbed doses were calculated by Monte Carlo simulations with the SHIELD-HIT07 code coupled with the mathematical anthropomorphic phantoms CHILD-HIT and ADAM-HIT. The simulated irradiations were performed with primary 1H, 4He, 7Li, 12C and 16O ion beams in the energy range 100–400 MeV/u which were directly impinging on the phantoms, i.e. approximating scanned beams, and with a simplified beamline for 12C irradiation. The evaluated absorbed doses to the out-of-field organs were in the range 10−6 to 10−1 mGy per target Gy and with standard deviations 0.5–20%. While the contribution to the organ absorbed doses from secondary neutrons dominated in the ion beams of low atomic number Z, the produced charged fragments and their subsequent charged secondaries of higher generations became increasingly important for the secondary dose delivery as Z of the primary ions increased. As compared to the simulated scanned 12C ion beam, the implementation of a simplified beamline for prostate irradiation with 12C ions resulted in an increase of 2–50 times in the organ absorbed doses depending on the distance from the target volume. Comparison of secondary organ absorbed doses delivered by 1H and 12C beams showed smaller differences when the RBE for local tumor control of the ions was considered and normalization to the RBE-weighted dose to the target was performed.
DOI：
10.1016/j.ijrobp.2009.01.001
发表时间：
2009-06-01
影响因子：
7
作者：
Fontenot, Jonas D.;Lee, Andrew K.;Newhauser, Wayne D.
通讯作者：
Newhauser, Wayne D.
DOI：
10.1016/s0360-3016(03)01574-8
发表时间：
2004-03-01
影响因子：
7
作者：
St Clair, WH;Adams, JA;Tarbell, NJ
通讯作者：
Tarbell, NJ