Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective.
Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective.
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DOI：
10.3389/fneur.2021.649452
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发表时间：
2021
影响因子：
3.4
通讯作者：
Cortes CJ
中科院分区：
文献类型：
--
作者：
Gupta R;Khan R;Cortes CJ
定期运动对于维持老化中枢神经系统健康的神经认知功能和中枢神经系统（CNS）免疫代谢发挥着重要作用。体力活动可降低患阿尔茨海默病 (AD) 的风险，与更好的 AD 预后相关，并对 AD 患者的认知功能产生积极影响。骨骼肌是一种重要的分泌器官，通过分泌统称为肌因子的生物活性分子，将蛋白质毒性和代谢应激传递给远处的组织，包括中枢神经系统。骨骼肌在运动过程中经历显着的物理和代谢重塑，包括肌因子表达谱的改变。这表明肌因子和肌代谢物分泌的变化可能是运动对 AD 有益的基础。然而，迄今为止，很少有研究关注骨骼肌源性分泌因子的具体改变及其在 AD 中的潜在神经保护作用。在这篇综述中，我们讨论了用于 AD 预防和干预的运动疗法，并建议使用循环肌因子作为改变 AD 进展的新型治疗工具。
Regular exercise plays an essential role in maintaining healthy neurocognitive function and central nervous system (CNS) immuno-metabolism in the aging CNS. Physical activity decreases the risk of developing Alzheimer's Disease (AD), is associated with better AD prognosis, and positively affects cognitive function in AD patients. Skeletal muscle is an important secretory organ, communicating proteotoxic and metabolic stress to distant tissues, including the CNS, through the secretion of bioactive molecules collectively known as myokines. Skeletal muscle undergoes significant physical and metabolic remodeling during exercise, including alterations in myokine expression profiles. This suggests that changes in myokine and myometabolite secretion may underlie the well-documented benefits of exercise in AD. However, to date, very few studies have focused on specific alterations in skeletal muscle-originating secreted factors and their potential neuroprotective effects in AD. In this review, we discuss exercise therapy for AD prevention and intervention, and propose the use of circulating myokines as novel therapeutic tools for modifying AD progression.
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影响因子：
3.4
作者：
Hook G;Jacobsen JS;Grabstein K;Kindy M;Hook V
通讯作者：
Hook V
跑步机跑步运动对中年APP/PS1转基因小鼠海马神经元影响的体视学研究
影响因子：
4
作者：
Chao, Fenglei;Jiang, Lin;Tang, Yong
通讯作者：
Tang, Yong
影响因子：
3.5
作者：
BAUER, J;STRAUSS, S;BERGER, M
通讯作者：
BERGER, M
DOI：
10.1126/science.aaw2622
发表时间：
2020-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Horowitz AM;Fan X;Bieri G;Smith LK;Sanchez-Diaz CI;Schroer AB;Gontier G;Casaletto KB;Kramer JH;Williams KE;Villeda SA
通讯作者：
Villeda SA
影响因子：
4.6
作者：
Chen W;Gao R;Xie X;Zheng Z;Li H;Li S;Dong F;Wang L
通讯作者：
Wang L