Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
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DOI：
10.1126/science.aaw2622
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发表时间：
2020-07-10
期刊：
影响因子：
--
通讯作者：
Villeda SA
中科院分区：
文献类型：
--
作者：
Horowitz AM;Fan X;Bieri G;Smith LK;Sanchez-Diaz CI;Schroer AB;Gontier G;Casaletto KB;Kramer JH;Williams KE;Villeda SA
通过系统干预，如运动，可以逆转大脑衰老。我们发现，从运动的老年小鼠的血浆中的循环血液因子的管理转移到久坐的老年小鼠的成年神经发生和认知的运动的影响。研究发现，运动后糖基磷脂酰肌醇（GPI）特异性磷脂酶D1（Gpld1）（一种来自肝脏的GPI降解酶）的血浆浓度增加，并与老年小鼠认知功能的改善相关，而在活跃的健康老年人中，血液中Gpld1的浓度增加。增加老年小鼠Gpld1的全身浓度，通过改变GPI锚定底物裂解下游的信号级联反应，改善了年龄相关的再生和认知障碍。因此，我们确定了一个肝脏到大脑的轴，血液因子可以通过这个轴转移老年运动的好处。
Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)–specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age.
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影响因子：
4.2
作者：
Kumar A;Rani A;Tchigranova O;Lee WH;Foster TC
通讯作者：
Foster TC
影响因子：
56.9
作者：
DAVITZ, MA;HERELD, D;NUSSENZWEIG, V
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NUSSENZWEIG, V
影响因子：
64.8
作者：
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通讯作者：
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影响因子：
2.2
作者：
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通讯作者：
GOSSNER, A
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
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