Drosophila unconventional myosin VI is involved in intra- and intercellular transport during oogenesis
Drosophila unconventional myosin VI is involved in intra- and intercellular transport during oogenesis
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果蝇非常规肌球蛋白 VI 参与卵子发生过程中的细胞内和细胞间运输
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Bohrmann
中科院分区：
文献类型：
--
作者：
J. Bohrmann
抽象的。在果蝇卵子发生中期，胞质颗粒在滋养细胞内通过环形通道（胞质桥）进入卵母细胞，这是一种依赖于微通道的机制。视频增强的荧光时间推移显微镜，结合显微注射的抗体针对果蝇95 F肌球蛋白，揭示了这种非常规的肌球蛋白的VI类参与运输过程。结果表明，某些细胞质颗粒在保育细胞移动沿着微丝，由于他们的直接协会与肌球蛋白VI马达。位于环管边缘的其他肌球蛋白- VI分子似乎参与了颗粒向卵母细胞的运输。显微注射的线粒体特异性染料揭示了这些颗粒中的一些是线粒体。
Abstract. During mid-oogenesis of Drosophila, cyto plasmic particles are transported within the nurse cells and through ring canals (cytoplasmic bridges) into the oocyte by means of a microfilament-dependent mecha nism. Video-intensified fluorescence timelapse mi croscopy, in combination with microinjections of antibodies directed against Drosophila 95F myosin, have revealed that this unconventional myosin of class VI is involved in the transport processes. The results indicate that certain cytoplasmic particles in the nurse cells move along microfilaments due to their direct association with myosin VI motors. Additional myosin- VI molecules located at the rim of the ring canals seem to be involved in particle transport into the oocyte. Microinjected mitochondria-specific dyes have revealed that some of these particles are mitochondria.
影响因子：
10.5
作者：
YUE, L;SPRADLING, AC
通讯作者：
SPRADLING, AC
DOI：
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发表时间：
1993-10
期刊：
The Journal of Cell Biology
影响因子：
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作者：
J. Wilhelm;R. Vale
通讯作者：
J. Wilhelm;R. Vale
影响因子：
10.4
作者：
Zhang, W;Croiset, E;Entchev, E
通讯作者：
Entchev, E