Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection
Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection
复制标题
疱疹病毒立即早期基因表达在巨细胞病毒感染细胞免疫中的意义
作者：
M. Reddehase;U. Koszinowski
间质性肺炎与因医源性免疫抑制引起的潜伏人巨细胞病毒再活化相关，可能是再生障碍性贫血和急性白血病骨髓移植治疗的严重并发症1。细胞免疫在人类和小鼠隐性巨细胞病毒感染的免疫监视中起关键作用1 -7。然而，潜伏期的分子基础，以及潜伏或复发感染的细胞与宿主免疫系统之间的相互作用却知之甚少。我们在小鼠模型中检测到一种迄今未知的抗原。该抗原在感染细胞中发现，与疱疹病毒“立即早期”基因的表达相关，并被溶细胞性T淋巴细胞（CTL）识别8。我们现在证明，一个出乎意料的高比例的CTL前体在体内产生的急性鼠巨细胞病毒感染过程中是特异性的细胞，选择性地合成立即早期蛋白，表明病毒的非结构蛋白的免疫显性作用。
Interstitial pneumonia linked with reactivation of latent human cytomegalovirus due to iatrogenic immunosuppression can be a serious complication of bone marrow transplantation therapy of aplastic anaemia and acute leukaemia1. Cellular immunity plays a critical role in the immune surveillance of inapparent cytomegalovirus infections in man and the mouse1–7. The molecular basis of latency, however, and the interaction between latently or recurrently infected cells and the immune system of the host are poorfy understood. We have detected a so far unknown antigen in the mouse model. This antigen is found in infected cells in association with the expression of the herpesvirus ‘immediate early’ genes and is recognized by cytolytic T lymphocytes (CTL)8. We now demonstrate that an unexpectedly high proportion of the CTL precursors generated in vivo during acute murine cytomegalovirus infection are specific for cells that selectively synthesize immediate early proteins, indicating an immunodominant role of viral non-structural proteins.
小鼠巨细胞病毒允许感染的小鼠胚胎细胞中的转录。
影响因子：
3.7
作者：
Marks,JR;Mercer,JA;Spector,DH
通讯作者：
Spector,DH
细胞毒性 T 淋巴细胞识别表达 SV40 肿瘤抗原片段的细胞。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gooding,LR;O'Connell,KA
通讯作者：
O'Connell,KA