Prevalence of the 4977-bp and 4408-bp mitochondrial DNA deletions in mesenteric arteries from patients with colorectal cancer
Prevalence of the 4977-bp and 4408-bp mitochondrial DNA deletions in mesenteric arteries from patients with colorectal cancer
复制标题
结直肠癌患者肠系膜动脉中 4977-bp 和 4408-bp 线粒体 DNA 缺失的患病率
DOI：
10.3109/19401736.2015.1079900
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发表时间：
2016-09
影响因子：
--
通讯作者：
Bo Zeng
中科院分区：
文献类型：
--
作者：
Gui-Lan Chen;Huan Lan;Liang Mao;Bo Zeng
摘要线粒体DNA(MtDNA)缺失广泛存在于多种病变组织中，导致线粒体功能受损。在这项研究中，我们发现在结直肠癌患者的肠系膜动脉线粒体DNA中广泛存在常见的4977个碱基和一个新的4408个碱基缺失。这两个缺失在健康个体的样本中也被检测到。4977个碱基缺失的mtDNA在健康对照组中的含量显著低于癌症相关样本，而4408个碱基缺失的线粒体DNA含量在两组间无显著差异。这些结果表明，癌细胞周围血管中的线粒体DNA可能受到氧化应激的强烈影响，并倾向于积累更多的大规模变异。
Abstract Mitochondrial DNA (mtDNA) deletions are found in many diseased tissues and lead to impairment of mitochondrial functions. In this study, we found wide presence of the common 4977-bp and a novel 4408-bp deletion in the mtDNA of mesenteric arteries from patients with colorectal cancer. These two deletions were also detected in samples from healthy individuals. The content of mtDNA with the 4977-bp deletion was significantly lower in healthy controls than cancer-associated samples, and there was no significant difference for the 4408-bp deletion between the two groups. These results suggest that mtDNA in blood vessels around cancer cells may be strongly affected by oxidative stress and tend to accumulate more large-scale variations.
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影响因子：
9.6
作者：
Lai, LP;Tsai, CC;Huang, SKS
通讯作者：
Huang, SKS
DOI：
--
发表时间：
2004-09
期刊：
Genetics and molecular research : GMR
影响因子：
--
作者：
M. Dani;S. U. Dani;Silmara P G Lima;Alfredo Martínez;B. Rossi;F. Soares;M. Zago;A. Simpson
通讯作者：
M. Dani;S. U. Dani;Silmara P G Lima;Alfredo Martínez;B. Rossi;F. Soares;M. Zago;A. Simpson
影响因子：
--
作者：
Alok K. Singh;P. Pandey;M. Tewari;H. Pandey;H. S. Shukla
通讯作者：
Alok K. Singh;P. Pandey;M. Tewari;H. Pandey;H. S. Shukla
影响因子：
3.9
作者：
Meissner, Christoph;Bruse, Petra;Oehmichen, Manfred
通讯作者：
Oehmichen, Manfred
DOI：
10.1111/j.1749-6632.2001.tb05640.x
发表时间：
2001-04
影响因子：
5.2
作者：
Yau-Huei Wei;Cheng‐Feng Lee;Hsin-Chen Lee;Yi‐Shing Ma;Chia‐Wen Wang;Ching‐You Lu;C. Pang
通讯作者：
Yau-Huei Wei;Cheng‐Feng Lee;Hsin-Chen Lee;Yi‐Shing Ma;Chia‐Wen Wang;Ching‐You Lu;C. Pang