Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome.
Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome.
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从持续性 BK 病毒尿症发展为持续性 BK 病毒血症且免疫抑制降低与 BK 病毒基因组非编码控制区的变化无关。
DOI：
10.1155/2012/761283
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发表时间：
2012
影响因子：
2.5
通讯作者：
Brennan,DanielC
中科院分区：
文献类型：
--
作者：
Memon,ImranA;Parikh,BijalA;Gaudreault-Keener,Monique;Skelton,Rebecca;Storch,GregoryA;Brennan,DanielC
Changes in the BK virus archetypal noncoding control region (NCCR) have been associated with BK‐virus‐associated nephropathy (BKVAN). Whether sustained viremia, a surrogate for BKVAN, is associated with significant changes in the BK‐NCCR is unknown. We performed PCR amplification and sequencing of (1) stored urine and (2) plasma samples from the time of peak viremia from 11 patients with sustained viremia who participated in a 200‐patient clinical trial. The antimetabolite was withdrawn for BK viremia and reduction of the calcineurin inhibitor for sustained BK viremia. DNA sequencing from the 11 patients with sustained viremia revealed 8 insertions, 16 transversions, 3 deletions, and 17 transitions. None were deemed significant. No patient developed clinically evident BKVAN. Our data support, at a genomic level, the effectiveness of reduction of immunosuppression for prevention of progression from viremia to BKVAN.
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DOI：
--
发表时间：
1974
期刊：
Recent Progress in Hormone Research
影响因子：
--
作者：
S. Cohen;C. Savage
通讯作者：
C. Savage
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DOI：
--
发表时间：
1972
期刊：
European Journal of Biochemistry
影响因子：
--
作者：
I. Covelli;R. Rossi;R. Mozzi;L. Frati
通讯作者：
L. Frati
影响因子：
4.4
作者：
Mamoru Marsuda;Mirsuru Sawa;H. Edelhauser;Stephen P. Barrels;Arthur H. Neufeld;Kenneth R. Kenyonj
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Mamoru Marsuda;Mirsuru Sawa;H. Edelhauser;Stephen P. Barrels;Arthur H. Neufeld;Kenneth R. Kenyonj
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DOI：
--
发表时间：
1987
期刊：
Ophthalmology (Rochester, Minn.)
影响因子：
--
作者：
J. Couch;Philippa R. Cullen;T. Casey;J. Fabre
通讯作者：
J. Fabre
表皮生长因子的选择性结合及其对角膜上皮细胞的特异性作用。
影响因子：
3.4
作者：
L. Frati;S. Daniele;A. Delogu;I. Covelli
通讯作者：
I. Covelli