Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach.
Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach.
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DOI：
10.1371/journal.pone.0245121
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Altai Z;Montefiori E;van Veen B;A Paggiosi M;McCloskey EV;Viceconti M;Mazzà C;Li X
最近，耦合肌肉骨骼有限元建模方法已经成为一种方法来调查股骨颈负荷在各种日常活动。将个性化步态数据与有限元模型相结合，不仅可以让我们研究运动/运动的变化，还可以研究它们对关键内部结构（如股骨）的影响。然而，以前的研究一直受到样本量小和缺乏完全个性化的数据，以构建耦合模型。因此，本研究的目的是建立一个完全个性化的多尺度（身体器官水平）模型的管道，以研究正常步态周期中股骨颈的应变水平。本研究纳入了5名绝经后女性。收集所有参与者的下肢CT和MRI扫描以及步态数据。肌肉力量来自身体水平的肌肉骨骼模型被用来作为边界约束的有限元股骨模型。在一个完整的步态周期中，估计股骨颈区域的主要应变。第一主应变峰值的平均值为0.24% ± 0.11%，第三主应变峰值的平均值为-0.29% ± 0.24%。对于四个人，最大应变的两个整体峰值被发现发生时，双脚与地板接触，而一个人有一个峰值在脚趾关闭阶段。关节接触力和肌肉力量被发现在很大程度上影响股骨颈的负载。预测的峰值应变与臀中肌（R2范围在0.95和0.99之间）之间的相关性高于髋关节接触力（R2范围在0.63和0.96之间）。因此，目前的研究结果表明，个人差异是巨大的，因此，重要的是要考虑多个科目之前得出的一般结论，为目标人群。
Recently, coupled musculoskeletal-finite element modelling approaches have emerged as a way to investigate femoral neck loading during various daily activities. Combining personalised gait data with finite element models will not only allow us to study changes in motion/movement, but also their effects on critical internal structures, such as the femur. However, previous studies have been hampered by the small sample size and the lack of fully personalised data in order to construct the coupled model. Therefore, the aim of this study was to build a pipeline for a fully personalised multiscale (body-organ level) model to investigate the strain levels at the femoral neck during a normal gait cycle. Five postmenopausal women were included in this study. The CT and MRI scans of the lower limb, and gait data were collected for all participants. Muscle forces derived from the body level musculoskeletal models were used as boundary constraints on the finite element femur models. Principal strains were estimated at the femoral neck region during a full gait cycle. Considerable variation was found in the predicted peak strain among individuals with mean peak first principal strain of 0.24% ± 0.11% and mean third principal strain of -0.29% ± 0.24%. For four individuals, two overall peaks of the maximum strains were found to occur when both feet were in contact with the floor, while one individual had one peak at the toe-off phase. Both the joint contact forces and the muscular forces were found to substantially influence the loading at the femoral neck. A higher correlation was found between the predicted peak strains and the gluteus medius (R2 ranged between 0.95 and 0.99) than the hip joint contact forces (R2 ranged between 0.63 and 0.96). Therefore, the current findings suggest that personal variations are substantial, and hence it is important to consider multiple subjects before deriving general conclusions for a target population.
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