Oral cyclosporine A--the current picture of its liposomal and other delivery systems.
Oral cyclosporine A--the current picture of its liposomal and other delivery systems.
复制标题
DOI：
10.2478/s11658-008-0041-6
复制
发表时间：
2009
影响因子：
8.3
通讯作者：
Czogalla A
中科院分区：
文献类型：
--
作者：
Czogalla A
环孢素A的发现是器官移植和自身免疫性疾病治疗的里程碑。然而，开发这种药物的有效口服给药系统由于其不良的生物制药特性（低溶解度和渗透性）以及需要仔细监测其在血液中的水平而变得复杂。目前的研究正在探索各种方法，包括基于乳剂、微球、纳米颗粒和脂质体的方法。虽然取得了进展，但没有一种提法是完美无缺的。这篇综述是一个简要的描述的主要药物系统和设备，已被描述为口服给药的环孢素A的药物的物理化学性质的背景下，其与脂质膜的相互作用的字符。
The discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its levels in the blood. Current research is exploring various approaches, including those based on emulsions, microspheres, nanoparticles, and liposomes. Although progress has been made, none of the formulations is flawless. This review is a brief description of the main pharmaceutical systems and devices that have been described for the oral delivery of cyclosporine A in the context of the physicochemical properties of the drug and the character of its interactions with lipid membranes.
登录
查看更多内容
DOI：
10.1016/s0939-6411(00)00143-0
发表时间：
2001-03-01
影响因子：
4.9
作者：
Gref, R;Quellec, P;Alonso, MJ
通讯作者：
Alonso, MJ
影响因子：
0.9
作者：
Busauschina, A;Schnuelle, P;van der Woude, FJ
通讯作者：
van der Woude, FJ
影响因子：
56.9
作者：
ALTSCHUH, D;VIX, O;THIERRY, JC
通讯作者：
THIERRY, JC
影响因子：
3.7
作者：
ARAMAKI, Y;TOMIZAWA, H;TSUCHIYA, S
通讯作者：
TSUCHIYA, S
影响因子：
7.3
作者：
Fricker, G;Drewe, J;Beglinger, C
通讯作者：
Beglinger, C