Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization.
Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization.
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DOI：
10.1016/j.ypmed.2012.04.009
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发表时间：
2012-06
影响因子：
5.1
通讯作者：
CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
中科院分区：
文献类型：
--
作者：
Godoy P;Castilla J;Delgado-Rodríguez M;Martín V;Soldevila N;Alonso J;Astray J;Baricot M;Cantón R;Castro A;González-Candelas F;Mayoral JM;Quintana JM;Pumarola T;Tamames S;Domínguez A;CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
本研究的目的是调查非药物干预在预防需要住院治疗的流感病例中的有效性。我们于2010年在西班牙的36家医院进行了一项多中心病例对照研究。每个病例选择经逆转录聚合酶链反应证实的住院流感病例和三个匹配的对照（两个医院和一个社区对照）。收集症状发作前7天使用的非药物措施（洗手频率、使用含酒精的洗手液和接触污染表面后洗手）。我们研究了813例因流感住院的病例和2274名对照。洗手5-10次（调整后的比值比[aOR] = 0.65）和> 10次（aOR = 0.59）以及接触污染表面后洗手（aOR = 0.65）的频率是保护因素，并具有剂量反应性（p < 0.001）。含酒精的洗手液与边际效益相关（aOR = 0.82）。应建议经常洗手，以预防需要住院治疗的流感病例。洗手与需要住院治疗的流感风险较低之间存在剂量反应关系。我们建议每天至少洗手5次。含酒精的洗手液与边际效益相关。
The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization. We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected. We studied 813 cases hospitalized for influenza and 2274 controls. The frequency of hand washing 5-10 times (adjusted odds ratio [aOR] = 0.65) and > 10 times (aOR = 0.59) and handwashing after contact with contaminated surfaces (aOR = 0.65) were protective factors and were dose-responsive (p < 0.001). Alcohol-based hand sanitizers were associated with marginal benefits (aOR = 0.82). Frequent handwashing should be recommended to prevent influenza cases requiring hospitalization. ► There is a dose-response relationship between hand washing and a lower risk of influenza requiring hospitalization ► We recommend hand washing at least 5 times a day ► Alcohol-based hand sanitizers were associated with marginal benefits.
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影响因子：
8
作者：
Roberts, L;Smith, W;McGilchrist, C
通讯作者：
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影响因子：
39.2
作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
TOSTOWARYK, W