Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model.
Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model.
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DOI：
10.1016/j.actbio.2014.07.011
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发表时间：
2014-11
影响因子：
9.7
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Kinard, Lucas A.;Dahlin, Rebecca L.;Lam, Johnny;Lu, Steven;Lee, Esther J.;Kasper, F. Kurtis;Mikos, Antonios G.
关键词：
临床上迫切需要一种更有效且更可靠的骨增量方法，而一种能对脱矿骨基质（DBM）进行精细调控释放的系统有可能满足这一需求。因此，本研究的目的是在大鼠模型中研究一种用于输送DBM以实现骨增量的合成可生物降解水凝胶。通过改变大鼠来源的DBM颗粒含量（以干重为基础，DBM:OPF的重量比分别为1:3、1:1或3:1）以及使用两种DBM粒径范围（50 - 150μm或150 - 250μm）来设计和制备寡聚（富马酸聚乙二醇酯）（OPF）构建体。对构建体的物理性质和DBM的生物活性进行了评估。选择一些配方（含有50 - 150μm DBM的1:1和3:1配方）与空白对照在体内进行评估，以研究DBM剂量和构建体特性对骨增量的影响。总体而言，DBM含量较高的3:1构建体实现的骨增量体积最大，分别比1:1构建体和空白植入物多3倍和5倍。因此，我们已经确定一种合成的可生物降解水凝胶可作为DBM的载体，并且构建体实现的骨增量体积与DBM剂量直接相关。
There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated in vivo compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation exceeding 1:1 constructs and empty implants by 3-fold and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlated directly to DBM dose.
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影响因子：
10.8
作者：
Martinez-Sanz, Elena;Ossipov, Dmitri A.;Varghese, Oommen P.
通讯作者：
Varghese, Oommen P.
影响因子：
3.7
作者：
Kinard, Lucas A.;Chu, Chia-Ye;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
4.1
作者：
Klijn, Reinoud J.;van den Beucken, Jeroen J. J. P.;Jansen, John A.
通讯作者：
Jansen, John A.
影响因子：
14.8
作者：
Kinard, Lucas A.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
DOI：
10.1016/j.jconrel.2013.03.013
发表时间：
2013-06-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Kim K;Lam J;Lu S;Spicer PP;Lueckgen A;Tabata Y;Wong ME;Jansen JA;Mikos AG;Kasper FK
通讯作者：
Kasper FK