MicroRNAs in adipogenesis and as therapeutic targets for obesity.
MicroRNAs in adipogenesis and as therapeutic targets for obesity.
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DOI：
10.1517/14728222.2011.561317
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发表时间：
2011-05
影响因子：
5.8
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Alexander R;Lodish H;Sun L
肥胖症和与肥胖症有关的疾病已达到流行病的程度，甚至在发展中国家也很普遍。脂肪组织越来越被认为是全身能量平衡的关键调节器，因此是代谢综合征的主要治疗靶点。这篇综述讨论了小的内源性表达的RNA，在转录后水平调节基因表达，在脂肪组织和其他相关的代谢组织的发育和功能的肥胖的影响。一些高通量研究已经鉴定了数百种在代谢组织发育过程中差异表达或作为病理生理学指标的miRNA。进一步的研究已经功能化了单个miRNA的调控能力，并揭示了这些miRNA的推定靶点。因此，与其他几种病理一样，miRNA正在成为代谢综合征的可行治疗靶点。本文综述了从间充质干细胞谱系决定到终末脂肪细胞分化的脂肪形成过程中所涉及的miRNAs。我们还讨论了在代谢病理生理过程中，脂肪组织中miRNAs的差异表达和其他代谢组织中miRNAs的失调。最后，我们讨论了靶向miRNA在肥胖症中的治疗潜力，并对基于miRNA的药物的挑战和优势进行了展望。miRNA是脂肪细胞发育和功能的广泛调节因子，并且是肥胖症的可行治疗靶标。尽管miRNA-靶标相互作用具有广谱性和冗余性，但复杂的生物信息学方法使确定疾病中最具生理相关性的miRNA成为可能。用于治疗目的的miRNA的体内递送正在迅速发展，并且在其他情况下已经成功。此外，miRNA可用作疾病发作和进展的预后标志物。最终，miRNAs是肥胖症及其在其他代谢组织中的后续病理的主要治疗靶点。
Obesity and obesity-related disease have reached pandemic proportions and are prevalent even in developing countries. Adipose tissue is increasingly being recognized as a key regulator of whole-body energy homeostasis and consequently as a prime therapeutic target for metabolic syndrome. This review discusses the roles of miRNAs, small endogenously expressed RNAs that regulate gene expression at a post-transcriptional level, in the development and function of adipose tissue and other relevant metabolic tissues impacted by obesity. Several high-throughput studies have identified hundreds of miRNAs that are differentially expressed during the development of metabolic tissues or as an indication of pathophysiology. Further investigation has functionalized the regulatory capacity of individual miRNAs and revealed putative targets for these miRNAs. Therefore, as with several other pathologies, miRNAs are emerging as feasible therapeutic targets for metabolic syndrome. This review provides a comprehensive view of miRNAs involved in adipogenesis, from mesenchymal stem cell lineage determination through terminal adipocyte differentiation. We also discuss the differential expression of miRNAs among adipose depots and the dysregulation of miRNAs in other metabolic tissues during metabolic pathophysiology. Finally, we discuss the therapeutic potential of targeting miRNAs in obesity and give a perspective on the challenges and advantages of miRNA-based drugs. miRNAs are extensive regulators of adipocyte development and function and are viable therapeutic targets for obesity. Despite the broad-spectrum and redundancy of miRNA–target interactions, sophisticated bioinformatic approaches are making it possible to determine the most physiologically relevant miRNAs to target in disease. In vivo delivery of miRNAs for therapeutic purposes is rapidly developing and has been successful in other contexts. Additionally, miRNAs can be used as prognosis markers for disease onset and progression. Ultimately, miRNAs are prime therapeutic targets for obesity and its consequent pathologies in other metabolic tissues.
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影响因子：
2.7
作者：
Herrera BM;Lockstone HE;Taylor JM;Wills QF;Kaisaki PJ;Barrett A;Camps C;Fernandez C;Ragoussis J;Gauguier D;McCarthy MI;Lindgren CM
通讯作者：
Lindgren CM
影响因子：
3.7
作者：
Favaro E;Ramachandran A;McCormick R;Gee H;Blancher C;Crosby M;Devlin C;Blick C;Buffa F;Li JL;Vojnovic B;Pires das Neves R;Glazer P;Iborra F;Ivan M;Ragoussis J;Harris AL
通讯作者：
Harris AL
影响因子：
120.1
作者：
Cao, Yihai
通讯作者：
Cao, Yihai
影响因子：
15.9
作者：
Johnson, JD;Ahmed, NT;Polonsky, KS
通讯作者：
Polonsky, KS
影响因子：
12.3
作者：
Gallagher IJ;Scheele C;Keller P;Nielsen AR;Remenyi J;Fischer CP;Roder K;Babraj J;Wahlestedt C;Hutvagner G;Pedersen BK;Timmons JA
通讯作者：
Timmons JA