Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.
Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.
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DOI：
10.1111/cas.13319
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发表时间：
2017-09
期刊：
影响因子：
5.7
通讯作者：
Torigoe T
中科院分区：
文献类型：
--
作者：
Shibayama Y;Tsukahara T;Emori M;Murata K;Mizushima E;Hirohashi Y;Kanaseki T;Nakatsugawa M;Kubo T;Yamashita T;Sato N;Torigoe T
化疗改善了肉瘤患者的预后。然而，它可能会抑制抗肿瘤免疫力。最近，我们报道了一种具有化学抗性的新型 CD8+ 记忆 T 细胞群，即“年轻记忆”T (TYM) 细胞。在这项研究中，我们调查了接受化疗和未接受化疗的健康供体和肉瘤患者外周血中 TYM 细胞的比例和功能。与健康供体相比，患者中TYM细胞的比例显着降低。在健康供体中，使用混合淋巴细胞肽培养物诱导抗 EBV CTL，不仅来自 TYM 细胞，还来自 TCM 和 TEM 细胞。没有诱导针对肿瘤相关抗原的 CTL。在未接受化疗的肉瘤患者中，除了抗 EBV CTL 之外，还从 TYM、TCM 和 TEM 细胞诱导出针对肿瘤相关抗原 PBF 的 CTL。在接受化疗的肉瘤患者中，EBV 特异性 CTL 是由 TYM 细胞诱导的，但几乎不是由 TEM 细胞诱导的。有趣的是，针对抗肿瘤相关抗原 PBF 的 CTL 是由 TYM 细胞诱导的，而不是由接受化疗的肉瘤患者的 TCM 和 TEM 细胞诱导的。研究结果表明，TYM细胞对化疗具有抵抗力，可以首先从最低点恢复过来。 TYM 细胞可能对免疫记忆很重要，尤其是在接受化疗的肉瘤患者中。
Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti‐tumor immunity. Recently, we reported a novel CD8+ memory T cell population with a chemo‐resistance property, “young memory” T (TYM) cells. In this study, we investigated the proportion and function of TYM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of TYM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti‐EBV CTLs were induced using mixed lymphocyte peptide culture, from not only TYM cells but also TCM and TEM cells. No CTLs directed to tumor‐associated antigens were induced. In sarcoma patients who did not receive chemotherapy, in addition to anti‐EBV CTLs, CTLs directed to the tumor‐associated antigen PBF were induced from TYM, TCM and TEM cells. In sarcoma patients who received chemotherapy, EBV‐specific CTLs were induced from TYM cells but were hardly induced from TEM cells. Interestingly, CTLs directed to the anti‐tumor‐associated antigen PBF were induced from TYM cells but not from the TCM and TEM cells in sarcoma patients who received chemotherapy. The findings suggest that TYM cells are resistant to chemotherapy and can firstly recover from the nadir. TYM cells might be important for immunological memory, especially in sarcoma patients receiving chemotherapy.
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DOI：
10.1038/nrc3322
发表时间：
2012-10
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Gattinoni L;Klebanoff CA;Restifo NP
通讯作者：
Restifo NP
对子集进行分类：哪些 T 细胞群介导高效的过继免疫疗法？
DOI：
10.1097/cji.0b013e31827806e6
发表时间：
2012-11
期刊：
Journal of immunotherapy (Hagerstown, Md. : 1997)
影响因子：
--
作者：
Klebanoff CA;Gattinoni L;Restifo NP
通讯作者：
Restifo NP
影响因子：
5.7
作者：
Morita R;Nishizawa S;Torigoe T;Takahashi A;Tamura Y;Tsukahara T;Kanaseki T;Sokolovskaya A;Kochin V;Kondo T;Hashino S;Asaka M;Hara I;Hirohashi Y;Sato N
通讯作者：
Sato N
影响因子：
64.8
作者：
Sallusto, F;Lenig, D;Lanzavecchia, A
通讯作者：
Lanzavecchia, A
影响因子：
7
作者：
Mittal, Deepak;Gubin, Matthew M.;Schreiber, Robert D.;Smyth, Mark J.
通讯作者：
Smyth, Mark J.