New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape.
New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape.
复制标题
DOI：
10.1016/j.coi.2014.01.004
复制
发表时间：
2014-04
影响因子：
7
通讯作者：
Smyth, Mark J.
中科院分区：
文献类型：
--
作者：
Mittal, Deepak;Gubin, Matthew M.;Schreiber, Robert D.;Smyth, Mark J.
癌症免疫编辑的原理为理解免疫对癌症的双重宿主保护和肿瘤雕刻作用奠定了基础，并为新型个体化癌症免疫治疗奠定了基础。在癌症免疫编辑过程中，宿主免疫系统通过激活先天性和适应性免疫机制分三个阶段塑造肿瘤命运。在第一阶段，消除，转化的细胞被一个有能力的免疫系统摧毁。设法在免疫破坏中存活下来的零星肿瘤细胞然后可以进入平衡阶段，在平衡阶段发生编辑。逃逸期代表了该过程的第三个也是最后一个阶段，其中免疫雕刻的肿瘤开始逐渐生长，变得临床明显并建立免疫抑制肿瘤微环境。本文重点介绍了最近的重要进展，这些进展增强了我们对癌症免疫编辑过程每个阶段的理解，总结了新的预测和预后生物标志物的发现，并讨论了新的客观有效的癌症免疫疗法的发展。
The principles of cancer immunoediting have set the foundations for understanding the dual host-protective and tumor sculpting actions of immunity on cancer and establishing the basis for novel individualized cancer immunotherapies. During cancer immunoediting, the host immune system shapes tumor fate in three phases through the activation of innate and adaptive immune mechanisms. In the first phase, Elimination, transformed cells are destroyed by a competent immune system. Sporadic tumor cells that manage to survive immune destruction may then enter an Equilibrium phase where editing occurs. The Escape phase represents the third and final phase of the process, where immunologically sculpted tumors begin to grow progressively, become clinically apparent and establish an immunosuppressive tumor microenvironment. This review focuses on important recent developments that have enhanced our understanding of each phase of the cancer immunoediting process, summarizes the discovery of new predictive and prognostic biomarkers and discusses development of novel and objectively effective cancer immunotherapies.
登录
查看更多内容
DOI：
10.1084/jem.20101159
发表时间：
2011-09-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fuertes MB;Kacha AK;Kline J;Woo SR;Kranz DM;Murphy KM;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
11.2
作者：
Halama, Niels;Michel, Sara;Jaeger, Dirk
通讯作者：
Jaeger, Dirk
影响因子：
64.8
作者：
DuPage, Michel;Mazumdar, Claire;Schmidt, Leah M.;Cheung, Ann F.;Jacks, Tyler
通讯作者：
Jacks, Tyler
影响因子：
64.8
作者：
Grivennikov, Sergei I.;Wang, Kepeng;Mucida, Daniel;Stewart, C. Andrew;Schnabl, Bernd;Jauch, Dominik;Taniguchi, Koji;Yu, Guann-Yi;Oesterreicher, Christoph H.;Hung, Kenneth E.;Datz, Christian;Feng, Ying;Fearon, Eric R.;Oukka, Mohamed;Tessarollo, Lino;Coppola, Vincenzo;Yarovinsky, Felix;Cheroutre, Hilde;Eckmann, Lars;Trinchieri, Giorgio;Karin, Michael
通讯作者：
Karin, Michael
DOI：
10.1084/jem.20101158
发表时间：
2011-09-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Diamond MS;Kinder M;Matsushita H;Mashayekhi M;Dunn GP;Archambault JM;Lee H;Arthur CD;White JM;Kalinke U;Murphy KM;Schreiber RD
通讯作者：
Schreiber RD