Coordination of biradial-to-radial symmetry and tissue polarity by HD-ZIP II proteins.
Coordination of biradial-to-radial symmetry and tissue polarity by HD-ZIP II proteins.
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DOI：
10.1038/s41467-021-24550-6
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发表时间：
2021-07-14
影响因子：
16.6
通讯作者：
Moubayidin L
中科院分区：
文献类型：
--
作者：
Carabelli M;Turchi L;Morelli G;Østergaard L;Ruberti I;Moubayidin L
对称的建立是多细胞器官发育的关键过程，当细胞在组织内积极分裂时，需要仔细协调极性轴。拟南芥雌蕊花柱的形成涉及到一个双边到径向对称的过渡过程，这是一个由植物形态素生长素动态分布支撑的渐进过程。本研究表明，SPATULA （SPT）和HECATE (HEC) bHLH蛋白介导花柱辐射过程的最后一步，并协同控制拟南芥同源基因HOMEOBOX 3 （HAT3）和拟南芥HOMEOBOX 4 （ATHB4）的表达。HAT3/ATHB4模块通过促进基部到根尖的生长素流动和通过抑制SPT表达和细胞分裂素敏感性微调生长素分布的负反馈机制来驱动根尖柱的辐射化。因此，这项工作揭示了拟南芥花柱对称转变过程中轴协调和激素串扰的分子基础。拟南芥的顶柱是由雌蕊的双侧向径向对称过渡形成的。在这里，作者表明花柱辐射的最后一步是由SPT和HEC转录因子诱导的近轴调节因子HAT3和ATHB4协调的。
Symmetry establishment is a critical process in the development of multicellular organs and requires careful coordination of polarity axes while cells actively divide within tissues. Formation of the apical style in the Arabidopsis gynoecium involves a bilateral-to-radial symmetry transition, a stepwise process underpinned by the dynamic distribution of the plant morphogen auxin. Here we show that SPATULA (SPT) and the HECATE (HEC) bHLH proteins mediate the final step in the style radialisation process and synergistically control the expression of adaxial-identity genes, HOMEOBOX ARABIDOPSIS THALIANA 3 (HAT3) and ARABIDOPSIS THALIANA HOMEOBOX 4 (ATHB4). HAT3/ATHB4 module drives radialisation of the apical style by promoting basal-to-apical auxin flow and via a negative feedback mechanism that finetune auxin distribution through repression of SPT expression and cytokinin sensitivity. Thus, this work reveals the molecular basis of axes-coordination and hormonal cross-talk during the sequential steps of symmetry transition in the Arabidopsis style. The apical style in Arabidopsis is formed following a bilateral-to-radial symmetry transition in the gynoecium. Here the authors show that the final step in style radialization is coordinated by the adaxial regulators HAT3 and ATHB4, which are induced by the SPT and HEC transcription factors.
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影响因子：
6.9
作者：
Carabelli M;Possenti M;Sessa G;Ruzza V;Morelli G;Ruberti I
通讯作者：
Ruberti I
影响因子：
4.5
作者：
Sawchuk MG;Edgar A;Scarpella E
通讯作者：
Scarpella E
DOI：
10.1242/dev.120444
发表时间：
2015-10-01
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Schuster C;Gaillochet C;Lohmann JU
通讯作者：
Lohmann JU
影响因子：
4.5
作者：
Reyes-Olalde JI;Zúñiga-Mayo VM;Serwatowska J;Chavez Montes RA;Lozano-Sotomayor P;Herrera-Ubaldo H;Gonzalez-Aguilera KL;Ballester P;Ripoll JJ;Ezquer I;Paolo D;Heyl A;Colombo L;Yanofsky MF;Ferrandiz C;Marsch-Martínez N;de Folter S
通讯作者：
de Folter S
影响因子：
4.6
作者：
Gremski, Kristina;Ditta, Gary;Yanofsky, Martin F.
通讯作者：
Yanofsky, Martin F.