Regulation of AMPA receptors in spinal nociception.
Regulation of AMPA receptors in spinal nociception.
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AMPA 受体在脊髓伤害感受中的调节
DOI：
10.1186/1744-8069-6-5
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发表时间：
2010-01-21
期刊：
影响因子：
3.3
通讯作者：
Fang L
中科院分区：
文献类型：
--
作者：
Wang Y;Wu J;Wu Z;Lin Q;Yue Y;Fang L
体外和体内研究表明，海马和小脑等不同脑区的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯（AMPA）受体的功能特性在LTP的亚基调控机制中具有独特性（长时程增强）和LTD（长时程抑制），其参与AMPA受体亚基的运输、改变组成和磷酸化。大量研究表明，脊髓AMPA受体在急性疼痛和持续性疼痛的发生机制中起着重要作用。然而，很少有人知道的AMPA受体亚单位在脊髓疼痛刺激反应的生化调节。近年来的研究表明，AMPA受体亚基的转运、亚基组成的变化、AMPA受体亚基的磷酸化以及它们与伴侣蛋白的相互作用等重要的调节过程可能参与脊髓伤害性信息的传递。在所有这些调节过程中，AMPA受体亚基的磷酸化是最重要的，因为它可以触发或影响其他细胞过程。因此，这些研究结果可能表明，在开发新的镇痛药靶向AMPA受体亚单位的调节，可能是有用的，在临床上没有不可接受的副作用治疗持续性和慢性疼痛的有效策略。
The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studiedin vitroandin vivo.The AMPA receptors present a unique characteristic in the mechanisms of subunit regulation during LTP (long-term potentiation) and LTD (long-term depression), which are involved in the trafficking, altered composition and phosphorylation of AMPA receptor subunits. Accumulated data have demonstrated that spinal AMPA receptors play a critical role in the mechanism of both acute and persistent pain. However, less is known about the biochemical regulation of AMPA receptor subunits in the spinal cord in response to painful stimuli. Recent studies have shown that some important regulatory processes, such as the trafficking of AMPA receptor subunit, subunit compositional changes, phosphorylation of AMPA receptor subunits, and their interaction with partner proteins may contribute to spinal nociceptive transmission. Of all these regulation processes, the phosphorylation of AMPA receptor subunits is the most important since it may trigger or affect other cellular processes. Therefore, these study results may suggest an effective strategy in developing novel analgesics targeting AMPA receptor subunit regulation that may be useful in treating persistent and chronic pain without unacceptable side effects in the clinics.
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影响因子：
9.2
作者：
Garry, EM;Moss, A;Fleetwood-Walker, SM
通讯作者：
Fleetwood-Walker, SM
影响因子：
64.8
作者：
Gu, JG;Albuquerque, C;MacDermott, AB
通讯作者：
MacDermott, AB
影响因子：
3.4
作者：
Katano, Tayo;Furue, Hidemasa;Ito, Seiji
通讯作者：
Ito, Seiji
影响因子：
56.9
作者：
Hayashi, Y;Shi, SH;Malinow, R
通讯作者：
Malinow, R
DOI：
10.1073/pnas.96.6.3269
发表时间：
1999-03-16
影响因子：
11.1
作者：
Derkach, V;Barria, A;Soderling, TR
通讯作者：
Soderling, TR