Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study
Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study
复制标题
日本普通人群中醛固酮合酶基因 (CYP11B2) C-334T 多态性、动态血压和夜间血压下降：Ohasama 研究
作者：
M. Matsubara;M. Kikuya;T. Ohkubo;H. Metoki;Fumiko Omori;Tohru Fujiwara;Michiko Suzuki;M. Michimata;A. Hozawa;T. Katsuya;J. Higaki;I. Tsuji;T. Araki;Toshio Ogihara;H. Satoh;S. Hisamichi;K. Nagai;Hirofumi Kitaoka;Y. Imai
目的 醛固酮合酶 (CYP11B2) 基因 5' 侧翼区域的 C-344T 多态性被认为通过影响醛固酮合成而与高血压和昼夜血压 (BP) 节律紊乱相关。然而，之前关于这个主题的研究结果并不一致。设计横断面研究。受试者和方法 我们调查了日本社区 802 名 40 岁及以上受试者的 CYP11B2 C-344T 基因型，这些受试者签署了书面知情同意书，并监测了 24 小时动态血压。结果这些日本受试者的 CC、CT 和 TT 基因型频率分别为 0.14、0.44 和 0.42，显示 T 等位基因频率 (0.64) 高于白种人。尽管基因型之间的 24 小时动态血压水平没有显着差异，但 CC 纯合子受试者的夜间血压下降明显大于其他受试者（夜间血压收缩压下降 P = 0.0065，舒张压下降 P = 0.031）。详细分析表明，这种关联仅在老年人（60 岁及以上）或男性受试者中显着。尽管年龄、体重指数、男性、吸烟、饮酒和抗高血压药物在三种基因型之间没有差异，但CC基因型受试者的既往心血管疾病患病率明显低于TC和TT基因型受试者。三种基因型的生化和激素参数没有显着差异。结论 虽然CYP11B2的C-344 T多态性不直接影响24小时血压水平，但CC基因型与日本老年人或男性夜间血压降低相关。由于纯合子 CC 受试者既往心血管疾病的患病率明显较低，因此该基因型夜间血压下降幅度更大似乎有利于昼夜血压节律。
Objective The C-344T polymorphism in the 5′-flanking region of the aldosterone synthase (CYP11B2) gene has been suggested to be associated with hypertension and disturbed circadian blood pressure (BP) rhythm through its effect on aldosterone synthesis. However, previous findings on this topic have been inconsistent. Design A cross-sectional study. Subjects and methods We investigated the CYP11B2 C-344T genotype in 802 subjects, aged 40 and over, in a Japanese community, who gave written informed consent and were monitored for 24 h ambulatory BP. Results The frequencies of the CC, CT, and TT genotypes in these Japanese subjects were 0.14, 0.44, and 0.42, showing a higher frequency of the T allele (0.64) than in Caucasians. Although there was no significant difference in 24 h ambulatory BP levels among the genotypes, the nocturnal decline in BP was significantly greater in the CC homozygous subjects than in other subjects (P = 0.0065 for systolic and P = 0.031 for diastolic decline in nocturnal BP). Detailed analyses demonstrated that this association was significant only in aged (60 years and over) or male subjects. The prevalence of previous cardiovascular disease was significantly less in these subjects with the CC genotype than in those with the TC and TT genotypes, although age, body mass index, male gender, smoking, use of alcohol and antihypertensive medication did not differ among the three genotypes. There was no significant difference among the three genotypes in biochemical and hormonal parameters. Conclusion Although the C-344 T polymorphism of CYP11B2 did not directly influence the level of 24 h BP, the CC genotype was associated with decreased nocturnal BP in elderly or male Japanese. Since prevalence of previous cardiovascular disease was significantly less in homozygous CC subjects, greater nocturnal BP decline in this genotype appears to be beneficial in the circadian BP rhythm.
影响因子：
37.8
作者：
M. Kupari;A. Hautanen;L. Lankinen;P. Koskinen;J. Virolainen;H. Nikkila;P. White
通讯作者：
M. Kupari;A. Hautanen;L. Lankinen;P. Koskinen;J. Virolainen;H. Nikkila;P. White
影响因子：
8.3
作者：
E. Seely;B. Walsh;M. Gerhard;Gordon H. Williams
通讯作者：
E. Seely;B. Walsh;M. Gerhard;Gordon H. Williams
DOI：
10.1001/jama.1988.03720020027031
发表时间：
1988-01
期刊：
JAMA
影响因子：
--
作者：
T. Pickering;G. James;Charlene Boddie;G. Harshfield;S. Blank;J. Laragh
通讯作者：
T. Pickering;G. James;Charlene Boddie;G. Harshfield;S. Blank;J. Laragh