3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin.
3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin.
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DOI：
10.3390/mi8080237
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发表时间：
2017-07-31
期刊：
影响因子：
3.4
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Liu H;Zhou H;Lan H;Liu T;Liu X;Yu H
3D打印已成为现代组织工程技术之一，可能形成支架（有或没有细胞），这对治疗心血管疾病很有用。该技术因其在组织工程和器官再生中治疗疾病的可能性而引起广泛关注。在本文中，我们已经开发了一种新的旋转成形装置，准备了一种海藻酸盐明胶溶液的血管状结构的制造，并进一步提出了一个理论模型来分析运动同步的参数。利用该旋转成形装置，首先建立了理论模型，分析了不同喷嘴挤压速度、喷嘴速度和伺服电机速度下的厚度。其次，利用海藻酸钠-明胶溶液在各种条件下构建血管状结构。实验结果表明，理论模型不能充分预测厚度，可以通过改变参数来控制厚度。最后，对优化后的厚度参数进行调整，以估算3D打印中的真实的厚度。
3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineering and organ regeneration. In this paper, we have developed a novel rotary forming device, prepared an alginate–gelatin solution for the fabrication of vessel-like structures, and further proposed a theoretical model to analyze the parameters of motion synchronization. Using this rotary forming device, we firstly establish a theoretical model to analyze the thickness under the different nozzle extrusion speeds, nozzle speeds, and servo motor speeds. Secondly, the experiments with alginate–gelatin solution are carried out to construct the vessel-like structures under all sorts of conditions. The experiment results show that the thickness cannot be adequately predicted by the theoretical model and the thickness can be controlled by changing the parameters. Finally, the optimized parameters of thickness have been adjusted to estimate the real thickness in 3D printing.
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影响因子：
14
作者：
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