Preoperative monocyte count is a predictor of recurrence after Stage I lung adenocarcinoma resection.
Preoperative monocyte count is a predictor of recurrence after Stage I lung adenocarcinoma resection.
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DOI：
10.1093/icvts/ivac005
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发表时间：
2022-06-01
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即使在I期肺腺癌中也观察到高级别肿瘤。肿瘤通过空气间隙扩散（STAS）是切除术后复发的危险因素。然而，对于高级别I期肺腺癌中的STAS没有理想的预测生物标志物。本研究评估了术前外周血单核细胞计数对肺腺癌预后的影响。我们回顾性分析了2006-2016年间444例I期肺腺癌切除患者的数据。无复发概率（RFP）和总生存期（OS）的单变量和多变量考克斯比例分析用于分析术前外周血细胞计数数据。由于单核细胞计数与不良预后相关，因此评估了术前外周血单核细胞计数与临床病理因素（包括STAS）之间的关系。此外，进行免疫组织化学CD 68染色以评价肿瘤相关巨噬细胞（TAM）。术前外周血单核细胞计数越高，RFP越低（P = 0.004），OS越低（P < 0.001）。在多变量分析中，较高的外周血单核细胞计数是RFP和OS的独立预后因素（风险比：1.88，95%置信区间：1.07-3.31，P = 0.029;风险比：2.13，95%置信区间：1.22-3.75，P = 0.008）。较高的外周血单核细胞计数与较高的STAS频率（P = 0.017）和较高的CD 68 + TAMs数量（P = 0.013）相关。术前较高的外周血单核细胞计数是I期肺腺癌预后不良的独立标志，并与STAS的发生率较高相关。早期肺腺癌最有益的治疗方法是手术;然而，超过10%的病理学IA期非小细胞肺癌（NSCLC）患者在接受根治性切除术后出现术后复发[1]。
High-grade tumours are observed even in Stage I lung adenocarcinomas. Tumour spread through air spaces (STAS) is a risk factor for recurrence after resection. However, there is no ideal predictive biomarker for STAS in high-grade Stage I lung adenocarcinoma. This study assessed the prognostic impact of the preoperative peripheral monocyte count in lung adenocarcinoma. We retrospectively analysed the data of 444 patients with resected Stage I lung adenocarcinoma during 2006–2016. Univariable and multivariable Cox proportional analyses of recurrence-free probability (RFP) and overall survival (OS) were used to analyze preoperative complete peripheral blood cell count data. Since monocyte count was associated with poor prognosis, the relationship between preoperative peripheral monocyte count and clinicopathological factors, including STAS, was assessed. In addition, immunohistochemical CD68 staining was performed to evaluate tumour-associated macrophages (TAMs). A higher preoperative peripheral monocyte count was a predictor of lower RFP (P = 0.004) and lower OS (P < 0.001). In multivariable analysis, a higher peripheral monocyte count was an independent prognostic factor for RFP and OS (hazard ratio: 1.88, 95% confidence interval: 1.07–3.31, P = 0.029; hazard ratio: 2.13, 95% confidence interval: 1.22–3.75, P = 0.008, respectively). A higher peripheral monocyte count was associated with a higher frequency of STAS (P = 0.017) and higher number of CD68+ TAMs (P = 0.013). A higher preoperative peripheral monocyte count was an independent marker for a poor prognosis in Stage I lung adenocarcinoma and was associated with a higher frequency of STAS. The most beneficial therapy for early-stage lung adenocarcinoma is surgery; however, more than 10% of patients with pathological Stage IA non-small cell lung cancer (NSCLC) exhibit postoperative recurrence after undergoing curative resection [1].
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DOI：
10.1038/nrclinonc.2016.217
发表时间：
2017-07
期刊：
Nature reviews. Clinical oncology
影响因子：
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作者：
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影响因子：
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