Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.
Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.
复制标题
清醒狗血浆皮质类固醇的生理增加对促肾上腺皮质激素的反馈抑制。
DOI：
10.1172/jci110840
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Dallman,MF
中科院分区：
文献类型：
--
作者：
Keller-Wood,ME;Shinsako,J;Dallman,MF
我们测试了清醒犬血浆皮质激素生理性增加对2小时后基础和低血糖刺激促肾上腺皮质激素（ACTH）水平的影响。α -1-24促肾上腺皮质激素或促肾上腺皮质激素输注40分钟后，血浆皮质激素升高，抑制了基础和刺激的促肾上腺皮质激素水平。注射促肾上腺皮质激素引起的血浆皮质激素增加所产生的抑制程度与输注皮质激素引起的血浆皮质激素同样增加所产生的抑制程度相当。注射0.1 U /kg胰岛素不影响基础血糖浓度，也不影响血浆葡萄糖浓度的下降。与低血糖刺激下的ACTH浓度相比，基础ACTH浓度对皮质类固醇诱导的抑制不敏感。在血浆皮质类固醇增加大约一半后，所有狗的基础分泌和刺激分泌都被显著抑制；最大的抑制发生在血浆皮质激素最大的增加之后。因此，血浆皮质激素的生理增加，类似于急性应激产生的生理增加，是随后应激诱导的ACTH分泌的有效抑制因子。图片
We have tested the effect of physiological increases in plasma corticosteroids in conscious dogs on the levels of basal and hypoglycemia-stimulated adrenocorticotropic hormone (ACTH) 2 h later. Increases in plasma corticosteroids, produced by infusion of alpha-1-24 ACTH or corticosteroids for 40 min, suppressed basal and stimulated ACTH levels. The magnitude of inhibition produced by an increase in plasma corticosteroids induced by the infusion of ACTH was equivalent to the inhibition produced by the same increase in plasma corticosteroids induced by corticosteroid infusion. The infusions did not affect basal plasma glucose concentrations or the decrease in plasma glucose concentrations after administration of 0.1 U insulin/kg. Basal ACTH concentration was less sensitive than hypoglycemia-stimulated ACTH concentration to corticosteroid-induced suppression. Basal and stimulated secretion were significantly inhibited in all dogs after approximately half-maximal increases in plasma corticosteroids; maximum inhibition occurred after maximal increases in plasma corticosteroids. Therefore, physiological increments in plasma corticosteroids, similar to those produced by acute stress, are effective suppressors of subsequent stress-induced ACTH secretion.Images
登录
查看更多内容
CALLA 阳性骨髓瘤：一种侵袭性亚型，生存率较差。
影响因子：
20.3
作者：
Durie,BG;Grogan,TM
通讯作者：
Grogan,TM
化疗后骨髓瘤蛋白动力学。
影响因子：
20.3
作者：
P. Mclaughlin;R. Alexanian
通讯作者：
R. Alexanian
更多关于辐射暴露和多发性骨髓瘤的信息。
影响因子：
158.5
作者：
T. Ishimaru;S. Finch
通讯作者：
S. Finch
骨髓单核细胞骨髓瘤细胞系（LB 84-1）。
影响因子：
20.3
作者：
B. Durie;T. Grogan;C. Spier;E. Vela;V. Baum;M. Rodriquez;Y. Frutiger
通讯作者：
Y. Frutiger
DOI：
--
发表时间：
1968
期刊：
Cancer chemotherapy reports. Part 3
影响因子：
--
作者：
Dilsha Siddiqui;U. Badar;Mahnoor Javaid;Nida Farooqui;S. Shah;Ayesha Iftikhar;F. Sultan;F. Mir;Sofia Furqan;S. Mahmood;S. Abidi
通讯作者：
S. Abidi