mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.
mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.
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DOI：
10.1186/s12967-021-03127-3
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发表时间：
2021-11-08
影响因子：
7.4
通讯作者：
Schu M
中科院分区：
文献类型：
--
作者：
Mathur R;Carnes MU;Harding A;Moore A;Thomas I;Giarrocco A;Long M;Underwood M;Townsend C;Ruiz-Esparza R;Barnette Q;Brown LM;Schu M
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种衰弱性疾病，涉及多个身体系统（如免疫、神经、消化、循环）和研究领域（如免疫学、代谢组学、肠道微生物组学、基因组学、神经学）。尽管经过几十年的研究，目前还没有确定的ME/CFS生物标志物可用于诊断和治疗ME/CFS。通过揭示诊断性生物标志物和促进发现新的有效疗法，共享数据和整合这些领域的发现对于提高对这种复杂疾病的理解至关重要。美国国立卫生研究院资助了一个数据共享门户网站的开发，以支持最初由三个受资助的研究中心组成的小组之间的协作努力。随后扩大到包括全球ME/CFS研究界。以开源综合知识档案网络（CKAN）框架为基础，ME/CFS数据管理和协调中心开发了一个具有元数据收集、智能搜索功能和与领域无关的数据集成的在线门户，以支持数据的可查找性和可重用性，同时减少可持续数据共享的障碍。我们设计了mapMECFS数据门户，通过允许ME/CFS研究人员在一个数据存储库中浏览、共享、比较和下载分子数据集，从而促进数据共享和集成。在发布时，mapMECFS包含从公共数据库、同行评审出版物和当前ME/CFS研究网络成员中策划的数据。mapMECFS是一个特定疾病的数据门户网站，旨在改善全球ME/CFS研究人员之间的数据共享和协作。mapMECFS可以通过注册向更广泛的研究社区开放。进一步的发展正在进行中，包括新的系统生物学和数据集成方法。在线版本包含补充材料，可在10.1186/s12967-021-03127-3获得。
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains (e.g., immunology, metabolomics, the gut microbiome, genomics, neurology). Despite several decades of research, there are no established ME/CFS biomarkers available to diagnose and treat ME/CFS. Sharing data and integrating findings across these domains is essential to advance understanding of this complex disease by revealing diagnostic biomarkers and facilitating discovery of novel effective therapies. The National Institutes of Health funded the development of a data sharing portal to support collaborative efforts among an initial group of three funded research centers. This was subsequently expanded to include the global ME/CFS research community. Using the open-source comprehensive knowledge archive network (CKAN) framework as the base, the ME/CFS Data Management and Coordinating Center developed an online portal with metadata collection, smart search capabilities, and domain-agnostic data integration to support data findability and reusability while reducing the barriers to sustainable data sharing. We designed the mapMECFS data portal to facilitate data sharing and integration by allowing ME/CFS researchers to browse, share, compare, and download molecular datasets from within one data repository. At the time of publication, mapMECFS contains data curated from public data repositories, peer-reviewed publications, and current ME/CFS Research Network members. mapMECFS is a disease-specific data portal to improve data sharing and collaboration among ME/CFS researchers around the world. mapMECFS is accessible to the broader research community with registration. Further development is ongoing to include novel systems biology and data integration methods. The online version contains supplementary material available at 10.1186/s12967-021-03127-3.
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影响因子：
8.6
作者：
Heller SR;McNaught A;Pletnev I;Stein S;Tchekhovskoi D
通讯作者：
Tchekhovskoi D
影响因子：
14.9
作者：
Hastings J;de Matos P;Dekker A;Ennis M;Harsha B;Kale N;Muthukrishnan V;Owen G;Turner S;Williams M;Steinbeck C
通讯作者：
Steinbeck C
影响因子：
7.4
作者：
Giloteaux L;O'Neal A;Castro-Marrero J;Levine SM;Hanson MR
通讯作者：
Hanson MR
影响因子：
3.7
作者：
Bouquet, Jerome;Li, Tony;Chiu, Charles Y.
通讯作者：
Chiu, Charles Y.
影响因子：
14.9
作者：
Maglott D;Ostell J;Pruitt KD;Tatusova T
通讯作者：
Tatusova T