Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor.
Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor.
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N-甲基-N-亚硝基脲在用表皮生长因子治疗的卵巢切除大鼠中诱导乳腺癌。
DOI：
10.1093/carcin/20.4.677
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发表时间：
1999
期刊：
影响因子：
4.7
通讯作者：
Nandi,S
中科院分区：
文献类型：
--
作者：
Chou,YC;Guzman,RC;Swanson,SM;Yang,J;Lui,HM;Wu,V;Nandi,S
表皮生长因子（EGF）在正常和恶性乳腺发育的重要性，在这些研究中提出。最初的研究结果表明，在没有卵巢激素的情况下，EGF对乳腺上皮细胞有显着的增殖作用。为了确定在没有卵巢激素的情况下，与EGF一起生长的乳腺上皮细胞是否可以被N-甲基-N-亚硝基脲（MNU）转化，将含有EGF的颗粒植入切除卵巢的雌性刘易斯大鼠1周，然后用MNU处理以开始转化。MNU治疗后两天，植入卵巢，并从所有卵巢切除组中取出EGF颗粒，以促进癌变。EGF刺激组的乳腺癌发生率（90%）与未刺激组（100%）无显著差异。EGF治疗的乳腺癌的形态是导管癌或筛状腺癌，而完整的动物主要是乳头状和偶尔筛状癌。EGF组中58%的癌是卵巢癌非依赖性的，而完整组中10%的癌是卵巢癌非依赖性的。这些结果表明，EGF诱导的增殖与MNU的启动过程中，足以诱导乳腺癌的转化，在卵巢激素的情况下。这些EGF诱导的癌的激素依赖性与MNU启动的乳腺癌在完整的大鼠相比是不同的。
The importance of epidermal growth factor (EGF) in both normal and malignant mammary gland development are presented in these studies. Initial findings demonstrated that in the absence of ovarian hormones, EGF had a significant proliferative effect on mammary epithelial cells. To determine whether mammary epithelial cells grown with EGF, in the absence of ovarian hormones, could be transformed byN-methyl-N-nitrosourea (MNU), female ovariectomized Lewis rats were implanted with pellets containing EGF for 1 week and then treated with MNU for initiation. Two days after MNU treatment, ovaries were implanted and EGF pellets were removed from all ovariectomized groups in order to promote carcinogenesis. The mammary carcinoma incidence of the EGF-stimulated group (90%) was not significantly different from the intact group (100%). The mammary cancer morphology of EGF-treated carcinomas was either ductal carcinoma or cribriform adenocarcinoma, whereas intact animals developed mainly papillary and occasional cribriform carcinomas. Fifty-eight percent of the carcinomas from the EGF group were ovarian hormone-independent compared with 10% of carcinomas from the intact group. These results demonstrate that EGF-induced proliferation during initiation with MNU was sufficient to induce the transformation of mammary carcinomas in the absence of ovarian hormones. The hormonal dependency of these EGF-induced carcinomas were different compared with MNU-initiated mammary carcinomas in intact rats.
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使用重组 ER (RER) 生产抗人雌激素受体蛋白 (ER) 的单克隆抗体
影响因子：
6.4
作者：
T. Saati;Edith Cohen‐Knafo;P. Caverivière;G. Delsol;S. Clamens;J. Faye;H. Prats;F. Bayard;J. Coindre;J. Wafflart
通讯作者：
J. Wafflart
雌激素和生长因子对正常和恶性人乳腺上皮细胞中转化生长因子-α和表皮生长因子受体表达的调节。
DOI：
10.1007/978-3-642-83638-1_8
发表时间：
1989
期刊：
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
影响因子：
--
作者：
D. S. Salomon;W. Kidwell;Nancy Kim;Fortunato Ciardiello;Susan E. Bates;E. Valverius;Marc E. Lippman;Robert B. Dickson;M. Stampfer
通讯作者：
M. Stampfer
DOI：
10.1007/978-1-4899-5043-7_1
发表时间：
1987
期刊：
Acta Pharmaceutica Sinica. B
影响因子：
--
作者：
C. Daniel;G. Silberstein
通讯作者：
G. Silberstein
早期激素环境的改变对致癌物诱发的大鼠乳腺肿瘤的发育和激素依赖性的影响。
影响因子：
11.2
作者：
Sylvester,PW;Aylsworth,CF;VanVugt,DA;Meites,J
通讯作者：
Meites,J
影响因子：
--
作者：
Sue C. Liu;Brunella Sanfilippo;Isabelle Perroteau;Rik Derynck;D. S. Salomon;W. Kidwell
通讯作者：
Sue C. Liu;Brunella Sanfilippo;Isabelle Perroteau;Rik Derynck;D. S. Salomon;W. Kidwell