Modulation by estrogen and growth factors of transforming growth factor-alpha and epidermal growth factor receptor expression in normal and malignant human mammary epithelial cells.
Modulation by estrogen and growth factors of transforming growth factor-alpha and epidermal growth factor receptor expression in normal and malignant human mammary epithelial cells.
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雌激素和生长因子对正常和恶性人乳腺上皮细胞中转化生长因子-α和表皮生长因子受体表达的调节。
DOI：
10.1007/978-3-642-83638-1_8
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Stampfer
中科院分区：
文献类型：
--
作者：
D. S. Salomon;W. Kidwell;Nancy Kim;Fortunato Ciardiello;Susan E. Bates;E. Valverius;Marc E. Lippman;Robert B. Dickson;M. Stampfer
许多特性明确的生长因子，如表皮生长因子（EGF）和胰岛素样生长因子（igf），可以刺激正常和恶性啮齿动物和人类乳腺上皮细胞的增殖并改变其分化（Salomon et al. 1986 A, c）。例如，EGF或转化生长因子- α (TGFa)可以在器官培养或体内刺激小鼠乳腺小叶-肺泡发育（Tonelli and Soroff 1980; Okamoto and Oka 1984; Vonderhaar 1987）。此外，EGF可能在小鼠妊娠和哺乳期乳腺发育以及乳腺肿瘤的自发形成中发挥生理作用（Okamoto和Oka 1984； Oka et al. 1987; Tsutsumi et al. 1987）。几种生长因子，如igf - 1、血小板衍生生长因子（PDGF）、tgf - fa和tgf - f，已在几种人乳腺癌细胞系的条件培养基（CM）中被发现（Salomon等，1984；Dickson等，1986；Huff等，1986；Bronzert等，1987；Knabbe等，1987；Peres等，1987）。TGF - fa、IGF-I和TGF/3的产生可被雌激素或抗雌激素调节，提示雌激素的促生长作用可能部分由TGF - fa和/或IGF-I介导，而抗雌激素的抑制生长作用可能由TGF/3介导（Dickson等人1985；Perroteau等人1986；Knabbe等人1987；Liu等人1987；Peres等人1987；Huff等人1988）。然而，目前尚不清楚这些或其他生长因子是否存在于体内乳腺肿瘤细胞中，如果存在，它们是否参与肿瘤发生和进展的病因学。同样，在乳腺发育的特定时期，类似生长因子在正常乳腺上皮细胞中的分布和表达水平也知之甚少。
A number of well-characterized growth factors, such as epidermal growth factor (EGF) and the insulin-like growth factors (IGFs), can stimulate the proliferation and modify the differentiation of normal and malignant rodent and human mammary epithelial cells (Salomon et al. 1986 a, c). For example, EGF or transforming growth factor-alpha (TGFa) can stimulate the lobulo-alveolar development of mouse mammary glands in organ culture or in vivo (Tonelli and Soroff 1980; Okamoto and Oka 1984; Vonderhaar 1987). In addition, EGF may perform a physiological role in the development of the mouse mammary gland during pregnancy and lactation and in the spontaneous formation of mammary tumors in mice (Okamoto and Oka 1984; Oka et al. 1987; Tsutsumi et al. 1987). Several of these growth factors, such as IGF-I, platelet-derived growth factor (PDGF), TGFa, and TGFs, have been found in the conditioned medium (CM) from several human breast cancer cell lines (Salomon et al. 1984; Dickson et al. 1986; Huff et al. 1986; Bronzert et al. 1987; Knabbe et al. 1987; Peres et al. 1987). The production of TGFa, IGF-I, and TGF/3 can be modulated by estrogens or anti-estrogens, suggesting that the growth-promoting effects of estrogen may be mediated in part by TGFa and/or IGF-I and that the growth-inhibitory effects of anti-estrogen may be mediated by TGF/3 (Dickson et al. 1985; Perroteau et al. 1986; Knabbe et al. 1987; Liu et al. 1987; Peres et al. 1987; Huff et al. 1988). However, it is still unclear whether these or other growth factors are present in mammary tumor cells in vivo and, if so, whether they are involved in the etiology of tumor development and progression. Likewise, there is little information on the distribution and level of expression of similar growth factors in normal mammary epithelial cells at specific times during the development of the mammary gland.
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影响因子：
11.2
作者：
R. Dickson;S. Bates;M. McManaway;M. Lippman
通讯作者：
R. Dickson;S. Bates;M. McManaway;M. Lippman
DOI：
10.1073/pnas.84.16.5763
发表时间：
1987-08-01
影响因子：
11.1
作者：
BRONZERT, DA;PANTAZIS, P;LIPPMAN, ME
通讯作者：
LIPPMAN, ME
转化生长因子α型的生物活性前体，由逆转录病毒转化细胞释放。
DOI：
10.1073/pnas.83.17.6307
发表时间：
1986
影响因子：
11.1
作者：
Ignotz,RA;Kelly,B;Davis,RJ;Massagué,J
通讯作者：
Massagué,J
影响因子：
--
作者：
BATES, SE;DAVIDSON, NE;SALOMON, DS
通讯作者：
SALOMON, DS
表皮生长因子和转化生长因子β对反式蛋白基因表达的转录调节。
影响因子：
5.3
作者：
Machida,CM;Muldoon,LL;Rodland,KD;Magun,BE
通讯作者：
Magun,BE