Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact.
Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact.
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DOI：
10.1002/wrna.1357
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Mühlemann O
中科院分区：
文献类型：
--
作者：
Karousis ED;Nasif S;Mühlemann O
无意义介导的信使核糖核酸衰变(NMD)最初是为了定义一种质量控制机制，该机制针对由于过早终止密码子的存在而截断开放阅读框架的mRNAs。与此同时，很明显，NMD对基因表达的影响要广泛得多，而且不断发现质量控制之外的其他生物功能。我们综述了目前关于NMD分子机制的观点，根据这些观点，NMD继而作用于未能正确终止翻译的mRNAs，并指出了我们理解上的差距。我们进一步总结了最近的文献，关于NMD似乎参与的一系列生物学过程，包括对基因表达、发育和分化的动态平衡控制，以及病毒防御。《电线RNA 2016》，7：661-682。DOI：10.1002/wrna.1357核糖核酸与蛋白质和其他分子的相互作用&蛋白质-核糖核酸相互作用：功能含义核糖核酸周转和监视>；核糖核酸周转/监视机制核糖核酸周转和监视>；核糖核酸稳定性调节本文归类如下：
Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. Meanwhile, it became clear that NMD has a much broader impact on gene expression and additional biological functions beyond quality control are continuously being discovered. We review here the current views regarding the molecular mechanisms of NMD, according to which NMD ensues on mRNAs that fail to terminate translation properly, and point out the gaps in our understanding. We further summarize the recent literature on an ever‐rising spectrum of biological processes in which NMD appears to be involved, including homeostatic control of gene expression, development and differentiation, as well as viral defense. WIREs RNA 2016, 7:661–682. doi: 10.1002/wrna.1357 RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability This article is categorized under:
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DOI：
10.1073/pnas.1000993107
发表时间：
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影响因子：
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