Normal Anti-Thyroid Peroxidase Antibody (TPO-Ab) Titers and Active Arterial Wall Thickening among Euthyroid Individuals: A Prospective Study.
Normal Anti-Thyroid Peroxidase Antibody (TPO-Ab) Titers and Active Arterial Wall Thickening among Euthyroid Individuals: A Prospective Study.
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DOI：
10.3390/jcm11030521
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发表时间：
2022-01-20
影响因子：
3.9
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nakamichi S;Nagata Y;Hayashida N;Maeda T
在甲状腺功能正常的个体中，根据颈动脉内膜中层厚度（CIMT）评估，抗甲状腺过氧化物酶抗体（TPO-Ab）滴度在正常范围内（阴性）与动脉粥样硬化呈正相关。动脉粥样硬化是心血管疾病的一个既定的危险因素，但CIMT的年度进展和心血管疾病之间没有显着的相关性。因此，阐明TPO-Ab滴度在正常范围内与CIMT每年进展之间的关联（即，活跃的动脉壁增厚）可能有助于为预防心血管疾病的策略提供信息。我们对1069名游离三碘甲状腺原氨酸和游离甲状腺素水平在正常范围内的日本受试者进行了一项前瞻性研究。TPO-Ab滴度在正常范围内与基线动脉粥样硬化显著正相关，与活动性动脉壁增厚显著负相关。校正已知混杂因素后，基线动脉粥样硬化和活动性动脉壁增厚的log（TPO-Ab滴度）的校正比值比（OR）和95%置信区间（CI）分别为2.16（1.07，4.35）和0.59（0.37，0.93）。由于CIMT的进展是一个积极的内皮修复过程，因此内皮修复缺陷会抑制主动动脉壁增厚。因此，正常高TPO-Ab滴度可能诱导内皮修复缺陷。
Among euthyroid individuals, having an anti-thyroid peroxidase antibody (TPO-Ab) titer in the normal range (negative) is positively associated with atherosclerosis as evaluated based on carotid intima-media thickness (CIMT). Atherosclerosis is an established risk factor for cardiovascular disease, but no significant association between yearly progression in CIMT and cardiovascular disease has been reported. Therefore, clarifying the association between having a TPO-Ab titer in the normal range and yearly progression in CIMT (i.e., active arterial wall thickening) among euthyroid individuals could help inform strategies for preventing cardiovascular disease. We conducted a prospective study of 1069 Japanese subjects with free triiodothyronine and free thyroxine levels within the normal range. Having a TPO-Ab titer in the normal range was significantly positively associated with baseline atherosclerosis and significantly inversely associated with active arterial wall thickening. After adjusting for known confounding factors, the adjusted odds ratio (OR) and 95% confidence interval (CI) of log (TPO-Ab titer) for baseline atherosclerosis and active arterial wall thickening was 2.16 (1.07, 4.35) and 0.59 (0.37, 0.93), respectively. Since progression in CIMT is a process of aggressive endothelial repair, deficient endothelial repair inhibits active arterial wall thickening. Therefore, high–normal TPO-Ab titers might induce a deficiency in endothelial repair.
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影响因子：
1.6
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
通讯作者：
Hayashida N
影响因子：
20.1
作者：
Patel RS;Li Q;Ghasemzadeh N;Eapen DJ;Moss LD;Janjua AU;Manocha P;Kassem HA;Veledar E;Samady H;Taylor WR;Zafari AM;Sperling L;Vaccarino V;Waller EK;Quyyumi AA
通讯作者：
Quyyumi AA
影响因子：
5.8
作者：
Raterman, H. G.;Voskuyl, A. E.;Nurmohamed, M. T.
通讯作者：
Nurmohamed, M. T.
影响因子：
5.4
作者：
Suzuki T;Wang W;Wilsdon A;Butler KR;Adabag S;Griswold ME;Nambi V;Rosamond W;Sotoodehnia N;Mosley TH
通讯作者：
Mosley TH
影响因子：
8.3
作者：
Polak JF;Pencina MJ;O'Leary DH;D'Agostino RB
通讯作者：
D'Agostino RB