Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.
Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.
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DOI：
10.1093/nar/gks281
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发表时间：
2012-07
影响因子：
14.9
通讯作者：
Perkins AS
中科院分区：
文献类型：
--
作者：
Bresnick EH;Katsumura KR;Lee HY;Johnson KD;Perkins AS
有许多例子表明，破坏血细胞发育的生理调节因子如何产生恶性血液病。造血干细胞/祖细胞的主要调节因子GATA-2在近20年前被克隆，并通过优雅的遗传分析证明了其促进造血的基本功能。虽然某些GATA-2靶基因与白血病发生有关，但直到最近才有明确的见解出现，将GATA-2与人类血液病理生理联系起来。这些病理生理包括骨髓增生异常综合征，急性髓性白血病和包括白血病在内的复杂表型免疫缺陷综合征。由于GATA-2在人类癌症的病因学中具有关键作用，因此考虑正常GATA因子功能/调节的机制以及如何剖析这些机制可能揭示在治疗背景下阻碍GATA-2依赖过程的独特机会具有指导意义。本文重点介绍了GATA因子的机制原理，重点介绍了GATA-1和GATA-2在造血系统中的功能，以及GATA-2失调与人体病理生理之间的新联系。
Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential function to promote hematopoiesis. While certain GATA-2 target genes are implicated in leukemogenesis, only recently have definitive insights emerged linking GATA-2 to human hematologic pathophysiologies. These pathophysiologies include myelodysplastic syndrome, acute myeloid leukemia and an immunodeficiency syndrome with complex phenotypes including leukemia. As GATA-2 has a pivotal role in the etiology of human cancer, it is instructive to consider mechanisms underlying normal GATA factor function/regulation and how dissecting such mechanisms may reveal unique opportunities for thwarting GATA-2-dependent processes in a therapeutic context. This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies.
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影响因子：
16
作者：
Crispino, JD;Lodish, MB;Orkin, SH
通讯作者：
Orkin, SH
DOI：
10.3324/haematol.2011.054361
发表时间：
2012-06-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Boedoer, Csaba;Renneville, Aline;Owen, Carolyn
通讯作者：
Owen, Carolyn
影响因子：
5.3
作者：
ARCECI, RJ;KING, AAJ;WILSON, DB
通讯作者：
WILSON, DB
影响因子：
4.6
作者：
Craven, SE;Lim, KC;Rosenthal, A
通讯作者：
Rosenthal, A
DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE