Sibling Donor Cord Blood Banking for Children with Sickle Cell Disease
Sibling Donor Cord Blood Banking for Children with Sickle Cell Disease
复制标题
镰状细胞病儿童的兄弟姐妹捐赠者脐带血库
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
B. Lubin
中科院分区：
文献类型：
--
作者：
W. Reed;M. Walters;E. Trachtenberg;Renée Smith;B. Lubin
虽然造血干细胞移植对镰状细胞病（SCD）患者具有治疗潜力，但大多数符合移植条件的患者没有合适的供体。来自兄弟姐妹的脐带血（CB）可以提供另一种干细胞来源，虽然不像骨髓那样成熟，但可能为选定的家庭提供某些优势。这些潜在的优势包括对婴儿供体的低风险，来自兄弟姐妹供体的不匹配的血球单位可能被移植接受，储存的血球单位可迅速用于移植，以及降低临床显著的移植物抗宿主病的风险。当患有SCD（或其他可移植治疗的疾病）的家庭怀上兄弟姐妹时，没有全面的研究资源来帮助家庭收集新生儿的CB。在国家心肺和血液研究所的支持下，我们正在开发一个非商业研究为基础的商业银行项目，专门用于医学上有指示的兄弟姐妹捐赠。根据初步经验，我们从19个州的52个SCD家庭收集了CB。其中，2个CB单位迄今已用于移植，另外9个是相同的hla。我们的结论是，建立一个专注于兄弟姐妹捐献的CB银行是可行的，但需要进一步的研究来确定这样一个银行是否能够收集足够数量和质量的CB单位来支持兄弟姐妹CB移植的对照试验。有特殊医疗需求的家庭，例如那些已经在照顾患有SCD的孩子的家庭，如果有机会，应该考虑收集兄弟姐妹的CB作为综合护理的一部分。
Although hematopoietic stem cell transplantation has curative potential for selected patients with sickle cell disease (SCD), most patients who are eligible for transplantation do not have a suitable donor. Cord blood (CB) from a sibling could provide an alternative stem cell source that, while not as well established as marrow, may offer certain advantages for selected families. These potential advantages include low risk to the infant donor, the possibility that mismatched CB units from sibling donors may be acceptable for transplantation, prompt availability of a stored CB unit for transplant, and decreased risk of clinically significant graft-versus-host disease. When families with SCD (or other transplant-treatable condition) conceive a sibling, no comprehensive research resource exists to assist the family in collecting the new infant's CB. With support from the National Heart Lung and Blood Institute, we are developing a noncommercial research-based CB Banking Program specifically for medically indicated sibling donations. In preliminary experience, we have collected CB from 52 SCD families across 19 states. Of these, 2 CB units have thus far been used for transplantation and 9 others are HLA-identical. We conclude that a CB bank focusing on sibling-donations may be feasible, but further study is required to determine whether such a bank can colled CB units of sufficient quantity and quality to support controlled trials of sibling CB transplantation. Families with a specific medical need, such as those already caring for a child with SCD, should consider collecting sibling CB as part of comprehensive care if the opportunity becomes available.
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影响因子：
158.5
作者：
GLUCKMAN, E;BROXMEYER, HE;BOYSE, EA
通讯作者：
BOYSE, EA
影响因子：
158.5
作者：
Rocha, V;Wagner, JE;Gluckman, E
通讯作者：
Gluckman, E
镰状细胞性贫血患者骨髓移植的相关捐献者的可用性。
DOI：
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发表时间：
1994
期刊：
The American journal of pediatric hematology/oncology
影响因子：
--
作者：
Mentzer,WC;Heller,S;Pearle,PR;Hackney,E;Vichinsky,E
通讯作者：
Vichinsky,E
镰状细胞性贫血骨髓移植的障碍。
DOI：
--
发表时间：
1996
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
影响因子：
--
作者：
Walters,MC;Patience,M;Leisenring,W;Eckman,JR;Buchanan,GR;Rogers,ZR;Olivieri,NE;Vichinsky,E;Davies,SC;Mentzer,WC;Powars,D;Scott,JP;Bernaudin,F;Ohene-Frempong,K;Darbyshire,PJ;Wayne,A;Roberts,IA;Dinndorf,P;Branda
通讯作者：
Branda
影响因子：
5.2
作者：
S. Davies
通讯作者：
S. Davies