Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population
Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population
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生发中心相关核蛋白多态性对日本人群乳腺癌风险和预后的影响
DOI：
10.1007/s12282-019-00956-5
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发表时间：
2019
期刊：
影响因子：
4
通讯作者：
Matsuo Keitaro
中科院分区：
文献类型：
--
作者：
Kotani Haruru;Ito Hidemi;Kuwahara Kazuhiko;Kuzushima Kiyotaka;Iwata Hiroji;Tsunoda Nobuyuki;Nagino Masato;Matsuo Keitaro
背景Germination center-associated nuclear protein（GANP）是一种参与mRNA输出和DNA重组调控的磷蛋白。虽然GANP在人乳腺癌组织中的表达与乳腺癌预后相关，但GANP的遗传背景与乳腺癌的易感性和预后之间的关联尚不清楚。2001年至2005年在爱知癌症中心进行。我们评估了GANP位点的两个多态性（rs 2839178和rs 11702450）对乳腺癌易感性和预后的影响。结果rs 2839178的GG基因型与乳腺癌的危险性显著相关（OR = 0.48，95%CI 0.30- 0.76，P = 0.002）。在预后分析中，与rs 2839178的AA基因型患者相比，AG或GG基因型患者的无病生存期（DFS）更长（HR分别为0.71，95%CI 0.49-1.04和0.42，95%CI 0.13 -1.42，P趋势= 0.04）。eQTL分析结果表明，rs 2839178与乳腺癌易感性的相关性可能与rs 2839173对GANP/MCM 3AP表达的影响有关。结论rs 2839178 GANP位点G等位基因与乳腺癌患者的乳腺癌发病风险降低和DFS延长显著相关，提示rs 2839178与乳腺癌易感性和临床预后的相关性方向一致。因此，GANP对散发性乳腺癌的发生和进展很重要。
BackgroundGerminal center-associated nuclear protein (GANP) is a phosphoprotein involved in mRNA export and regulation of DNA recombination. Although GANP expression in human breast cancer tissue is associated with breast cancer prognosis, the association between the genetic background of GANP and susceptibility and prognosis of breast cancer is unclear.MethodsWe selected 694 breast cancer cases and 1376 age- and menopausal status-matched non-cancer controls from the Hospitable-based Epidemiologic Research Program, conducted at Aichi Cancer Center between 2001 and 2005. We evaluated the impact of two polymorphisms at theGANPlocus (rs2839178 and rs11702450) on the susceptibility and prognosis of breast cancer. Reference alleles were defined as the A allele for rs2839178 and G allele for rs11702450.ResultsThe GG genotype of rs2839178 was statistically significantly associated with breast cancer risk (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.30–0.76,P= 0.002). In prognostic analysis, compared to those with AA genotype of rs2839178, patients with AG or GG genotypes had longer disease-free survival (DFS) (hazard ratio [HR] 0.71, 95% CI 0.49–1.04 and HR 0.42, 95% CI 013–1.42, respectively,Pfor trend = 0.04). eQTL analysis indicated that association with rs2839178 can be explained by the effect of rs2839173 on expression of GANP/MCM3AP.ConclusionsThe G allele of rs2839178 at theGANPlocus was significantly associated with reduced breast cancer risk and longer DFS in breast cancer patients, showing a consistent direction in the association between susceptibility and clinical outcome. GANP is, therefore, important for the occurrence and progression of sporadic breast cancer.
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影响因子：
5.7
作者：
Ohta, Kazutaka;Kuwahara, Kazuhiko;Sakaguchi, Nobuo
通讯作者：
Sakaguchi, Nobuo
通过直接重复β-半乳糖苷酶基因构建体测量，GANP 抑制 DNA 重组，但不抑制哺乳动物细胞中免疫球蛋白基因的重组类型。
DOI：
--
发表时间：
2007
期刊：
Genes Cells 12
影响因子：
--
作者：
Mikoto Yoshida;Kazuhiko Kuwahara;Tatsuya Shimasaki;Naomi Nakagata;Masao Matsuoka;Nobuo Sakaguchi
通讯作者：
Nobuo Sakaguchi
癌症控制研究2001。
DOI：
10.1023/a:1008953206396
发表时间：
2000
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Rimer,BK
通讯作者：
Rimer,BK
DOI：
--
发表时间：
2000
期刊：
Asian Pacific J.Cancer Prev. 1
影响因子：
--
作者：
Tajima;K.
通讯作者：
K.
影响因子：
56.9
作者：
MIKI, Y;SWENSEN, J;SKOLNICK, MH
通讯作者：
SKOLNICK, MH