KnotProt: a database of proteins with knots and slipknots.

KnotProt: a database of proteins with knots and slipknots.
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DOI:
10.1093/nar/gku1059
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发表时间:
2015-01
影响因子:
14.9
通讯作者:
Sulkowska JI
Sulkowska JI
中科院分区:
生物学2区
文献类型:
--
作者:
Jamroz M;Niemyska W;Rawdon EJ;Stasiak A;Millett KC;Sułkowski P;Sulkowska JI

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蛋白质拓扑学数据库KnotProt,http://knotprot.cent.uw.edu.pl/,收集关于具有形成结或滑结的开放多肽链的蛋白质结构的信息。编目蛋白质的打结复杂性以矩阵图的形式呈现,该矩阵图向用户显示整个多肽链及其每个子链的结类型。矩阵中可见的模式给出了给定蛋白质的打结指纹,并允许用户确定例如打结区域的最小长度(结的核心大小)或结的深度,即在将其从结转换为不同类型的结之前,可以从编目蛋白质结构的任一端去除多少氨基酸。此外,该数据库还提供了关于具有非平凡打结的蛋白质的生物学功能、家族和折叠类型的广泛信息。作为一个额外的功能,KnotProt数据库使用户能够提交蛋白质或聚合物链,并生成他们的打结指纹。
The protein topology database KnotProt, http://knotprot.cent.uw.edu.pl/, collects information about protein structures with open polypeptide chains forming knots or slipknots. The knotting complexity of the cataloged proteins is presented in the form of a matrix diagram that shows users the knot type of the entire polypeptide chain and of each of its subchains. The pattern visible in the matrix gives the knotting fingerprint of a given protein and permits users to determine, for example, the minimal length of the knotted regions (knot's core size) or the depth of a knot, i.e. how many amino acids can be removed from either end of the cataloged protein structure before converting it from a knot to a different type of knot. In addition, the database presents extensive information about the biological functions, families and fold types of proteins with non-trivial knotting. As an additional feature, the KnotProt database enables users to submit protein or polymer chains and generate their knotting fingerprints.
DOI: 10.1093/nar/gks1211
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影响因子: 14.9
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