Does moderate to vigorous physical activity mediate the association between depression and physical function in midlife: Evidence from two British birth cohort studies.
Does moderate to vigorous physical activity mediate the association between depression and physical function in midlife: Evidence from two British birth cohort studies.
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中度至剧烈的体力活动是否介导抑郁症与中年身体机能之间的关联：来自两项英国出生队列研究的证据。
DOI：
10.1016/j.jad.2022.12.084
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发表时间：
2023
影响因子：
6.6
通讯作者：
Blodgett JM
中科院分区：
文献类型：
--
作者：
Blodgett JM
心理健康和身体健康有着内在的联系，但其机制尚不清楚。我们研究了中等强度体力活动（MVPA）是否介导了中年抑郁与身体功能（PF）之间的关联。方法：来自1958年（n= 7278）和1970年（n= 6097）在一周内出生的两个英国出生队列的个体，他们有抑郁症（33/34岁；萎靡不振）、MVPA（42岁；自我报告）和PF（50/56岁；短表-36子量表）的数据。协变量包括性别、童年和成年社会阶层、母亲心理健康、童年情绪、饮酒、吸烟习惯、睡眠、婚姻状况、体重指数和长期疾病/残疾。线性或多项式逻辑回归模型检验了抑郁、MVPA和PF之间的关联，我们使用参数g计算中介分析方法估计了PF的百分比差异。结果抑郁与MVPA频率较低和PF较差相关，MVPA较低与PF较差相关。在1958年和1970年的队列中，抑郁对PF的直接影响- 95%CI:- 25.8,-11.8)和- 15.8% （95%CI:- 25.8,-11.8）和- 15.8% （95%CI:- 20.6,-11.0）。分别。间接效应-通过MVPA操作-为- 0.5%（- 1.0,-0.03）和- 0.2%(- 0.6,0.3)，导致总比例为3.1%（0.1,6.0）和0.9%（- 1.6,3.4）。局限性：smvpa为自我报告。在相同年龄测量中间混杂因素和中介因素，但考虑到年龄46岁的MVPA（1958队列），相关性在敏感性分析中没有变化。结论虽然较高的MVPA对不良PF有保护作用，但只有少量证据表明它介导了抑郁和PF之间的关联，需要进一步研究心理到身体健康途径的其他潜在介质。
BackgroundMental health and physical health are intrinsically linked, yet the mechanisms are not well understood. We investigated whether moderate-vigorous physical activity (MVPA) mediated the association between depression and physical function (PF) in midlife.MethodsIndividuals from two UK birth cohorts born within one week in 1958 (n= 7278) and 1970 (n= 6097) with data on depression (ages 33/34; Malaise Inventory), MVPA (age 42; self-reported) and PF (ages 50/56; Short Form-36 subscale). Covariates included sex, childhood and adulthood social class, maternal mental health, childhood mood, alcohol consumption, smoking habits, sleep, marital status, BMI and long-standing illness/disability. Linear or multinomial logistic regression models examined associations between depression, MVPA and PF. We used a parametric g-computation mediation analysis approach to estimate percent differences in PF.ResultsDepression was associated with less frequent MVPA and poorer PF. Lower MVPA was associated with worse PF. The direct effect – randomised analogue not operating via MVPA – of depression on PF was −18.8 % (95%CI:--25.8,-11.8) and −15.8 % (20.6,-11.0) in the 1958 and 1970 cohorts, respectively. The indirect effect – operating via MVPA – was −0.5 % (−1.0,-0.03) and −0.2 % (−0.6, 0.3), resulting in a total proportion mediated of 3.1 % (0.1, 6.0) and 0.9 % (−1.6, 3.4).LimitationsMVPA was self-reported. Intermediate confounders and mediators were measured at the same age, however associations did not change in sensitivity analysis considering age 46 MVPA (1958 cohort).ConclusionsAlthough higher MVPA was protective against poor PF, there was only minor evidence that it mediated the association between depression and PF. Further investigation into other potential mediators of pathways from mental to physical health is needed.
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影响因子：
11.7
作者：
Rollo S;Antsygina O;Tremblay MS
通讯作者：
Tremblay MS
DOI：
10.1016/j.bbi.2022.03.008
发表时间：
2022-05
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
通讯作者：
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体育锻炼作为癫痫和抑郁症患者的应对策略
影响因子：
2.6
作者：
R. Vancini;C. A. Lira;R. Arida
通讯作者：
R. Arida
影响因子：
5.3
作者：
Laursen, Thomas Munk;Munk-Olsen, Trine;Mortensen, Preben Bo
通讯作者：
Mortensen, Preben Bo
影响因子：
12.1
作者：
Ferreira, Manuela L.;Sherrington, Catherine;Vardon, Paul
通讯作者：
Vardon, Paul