Subcutaneous adipose tissue classification.
Subcutaneous adipose tissue classification.
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DOI：
10.4081/ejh.2010.e48
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发表时间：
2010-11-25
期刊：
影响因子：
--
通讯作者：
Panettiere P
中科院分区：
文献类型：
--
作者：
Sbarbati A;Accorsi D;Benati D;Marchetti L;Orsini G;Rigotti G;Panettiere P
以使用自体脂肪组织为基础的技术的发展吸引了人们对小型仓库作为可能的采样区的关注。其中一些仓库从未被详细研究过。本研究对不同地区的皮下脂肪库进行了采样，目的是解释它们的形态，特别是关于茎的壁龛。结果表明，根据白色脂肪组织的结构和超微结构特征，可将其分为三种类型：沉积白色脂肪组织(DWAT)、结构白色脂肪组织(SWAT)和纤维白色脂肪组织(FWAT)。DWAT主要存在于腹部(脐周)的大型脂肪储存区。在dWAT中，细胞被紧密地包裹在一起，并由一张由分离的胶原纤维组成的薄弱网络连接起来。胶原成分很少，细胞大，血管少。深层比浅层看起来更具纤维性。微循环是由具有稀有的茎凹的薄壁毛细血管形成的。强化的周细胞成分很少明显。特警队更多的是间质；它位于肢体和臀部的一些区域。间质表现良好，有良好的血管和足够的耐力。细胞被一篮子胶原纤维包裹着。膝关节和粗隆部位的脂肪储存处有相当松散的网状结构。FWAT具有值得注意的纤维成分，可以在发生严重机械应力的区域找到。脂肪细胞有一个单独的厚纤维壳。综上所述，本研究显示不同的皮下脂肪沉积有明显的差异，因此，在基于自体脂肪组织的再生手术中，采样区域不应随机选择，而应以循证评估为导向。SWAT的结构特点，特别是其微循环，表明它可能是以自体脂肪组织为基础的再生手术的特权来源。
The developments in the technologies based on the use of autologous adipose tissue attracted attention to minor depots as possible sampling areas. Some of those depots have never been studied in detail. The present study was performed on subcutaneous adipose depots sampled in different areas with the aim of explaining their morphology, particularly as far as regards stem niches. The results demonstrated that three different types of white adipose tissue (WAT) can be differentiated on the basis of structural and ultrastructural features: deposit WAT (dWAT), structural WAT (sWAT) and fibrous WAT (fWAT). dWAT can be found essentially in large fatty depots in the abdominal area (periumbilical). In the dWAT, cells are tightly packed and linked by a weak net of isolated collagen fibers. Collagenic components are very poor, cells are large and few blood vessels are present. The deep portion appears more fibrous then the superficial one. The microcirculation is formed by thin walled capillaries with rare stem niches. Reinforcement pericyte elements are rarely evident. The sWAT is more stromal; it is located in some areas in the limbs and in the hips. The stroma is fairly well represented, with a good vascularity and adequate staminality. Cells are wrapped by a basket of collagen fibers. The fatty depots of the knees and of the trochanteric areas have quite loose meshes. The fWAT has a noteworthy fibrous component and can be found in areas where a severe mechanic stress occurs. Adipocytes have an individual thick fibrous shell. In conclusion, the present study demonstrates evident differences among subcutaneous WAT deposits, thus suggesting that in regenerative procedures based on autologous adipose tissues the sampling area should not be randomly chosen, but it should be oriented by evidence based evaluations. The structural peculiarities of the sWAT, and particularly of its microcirculation, suggest that it could represent a privileged source for regenerative procedures based on autologous adipose tissues.
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影响因子：
8
作者：
Sbarbati, A;Osculati, F;Maffeis, C
通讯作者：
Maffeis, C
影响因子：
5.2
作者：
Constantin, Gabriela;Marconi, Silvia;Bonetti, Bruno
通讯作者：
Bonetti, Bruno
影响因子：
2.4
作者：
Panettiere, P;Marchetti, L;Del Gaudio, GA
通讯作者：
Del Gaudio, GA
影响因子：
3.6
作者：
Rigotti, Gino;Marchi, Alessandra;Sbarbati, Andrea
通讯作者：
Sbarbati, Andrea
影响因子：
3.7
作者：
Peroni, Daniele;Scambi, Ilaria;Galie, Mirco
通讯作者：
Galie, Mirco