Second Neoplasms in Pediatric Patients Treated for Cancer: A Center's 30-year Experience
Second Neoplasms in Pediatric Patients Treated for Cancer: A Center's 30-year Experience
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接受癌症治疗的儿科患者的二次肿瘤：一个中心 30 年的经验
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Münevver Bu¨yu¨kpamukçu
中科院分区：
文献类型：
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作者：
K. Çağlar;A. Varan;C. Akyüz;U. Selek;T. Kutluk;B. Yalçın;I. Lale Atahan;Münevver Bu¨yu¨kpamukçu
目的探讨儿童癌症治疗后继发肿瘤的发生率和转归。1971年12月至2000年1月，我中心共收治年龄在17岁以下的儿童癌症患者5859例。在这组患者中，1511名(36%)患者获得了超过36个月的随访。这些长期的幸存者被包括在这项分析中。在这个队列中，26名患者发展为继发性恶性肿瘤，总体风险为1.7%。男女之比为17：10，确诊时年龄中位数为7.66岁(2~16 y)。其中霍奇金淋巴瘤4例(14.8%)，视网膜母细胞瘤和横纹肌肉瘤各3例(11.1%)，肾母细胞瘤、尤文肉瘤、髓母细胞瘤、神经节神经母细胞瘤和非霍奇金淋巴瘤各2例(7.4%)，室管膜瘤、鼻咽癌、骨肉瘤、星形细胞瘤各1例(3.7%)。继发恶性疾病：骨肉瘤6例，急性淋巴细胞性白血病2例，急性髓系白血病2例，其他少见恶性肿瘤。4名骨肉瘤患者在照射野内出现疾病。骨肉瘤是最常见的继发性肿瘤。应使用毒性较低的治疗方法，以降低继发性恶性疾病的风险。
To investigate the incidence and outcome of secondary neoplasms in pediatric patients treated for childhood cancer. Between December 1971 and January 2000, a total of 5859 patients younger than age 17 were diagnosed and treated for childhood cancers in our center. Of this group, 1511 (36%) patients were followed for more than 36 months. These long-term survivors were included in this analysis. Twenty-six patients developed a secondary malignancy with an overall risk of 1.7% in this cohort. The male:female ratio was 17:10, with a median age of 7.66 at diagnosis (range, 2 to 16 y). Four patients (14.8%) with Hodgkin lymphoma; 3 each (11.1%) with retinoblastoma and rhabdomyosarcoma; 2 each (7.4%) with Wilms tumor, Ewing sarcoma, medulloblastoma, ganglioneuroblastoma, and non-Hodgkin lymphoma; and 1 each (3.7%) with ependymoma, nasopharyngeal carcinoma, osteosarcoma, astrocytoma had a secondary malignant disease during the long-term follow-up period. Secondary malignant diseases were osteosarcoma in 6 patients, acute lymphoblastic leukemia in 2, acute myelogenous leukemia in 2, and rare malignant disease in others. Four patients with osteosarcoma developed disease within the radiation field. Osteosarcoma was the most frequently occurring secondary neoplasm. Less toxic treatment modalities should be used to decrease the risk of secondary malignant diseases.
DOI：
10.1002/mpo.1316
发表时间：
2002-04-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
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作者：
Robison, LL;Mertens, AC;Zeltzer, LK
通讯作者：
Zeltzer, LK
DOI：
10.1002/mpo.1125
发表时间：
2001-05-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
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作者：
Felix, CA
通讯作者：
Felix, CA
影响因子：
45.3
作者：
Kuttesch, JF;Wexler, LH;Kun, LE
通讯作者：
Kun, LE