Vasotocin and mesotocin in the brains of amphibians: State of the art

Vasotocin and mesotocin in the brains of amphibians: State of the art
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两栖动物大脑中的加压素和中产素:最新技术

DOI:
10.1002/jemt.1128
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发表时间:
2001
影响因子:
2.5
通讯作者:
Agustín González
Agustín González
中科院分区:
工程技术3区
文献类型:
--
作者:
W. Smeets;Agustín González

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在过去的十年中,免疫组织化学研究揭示了包括无尾两栖动物、尾巴动物和裸体动物在内的各种两栖动物大脑中复杂的血管烟碱能(AVT)和中烟碱能(MST)神经元成分系统。除了发育良好的下丘脑-垂体系统外,抗体还证明了下丘脑外AVT和MST免疫反应细胞群的存在以及下丘脑外广泛的免疫反应纤维网络的存在。AVT和MST免疫反应纤维在两栖动物脑内的广泛分布表明,这两个神经肽能系统不仅参与下丘脑-垂体的相互作用,而且还参与其他多种脑功能。此外,现在有证据表明,在两栖动物中出现了与性别有关的差异,就像之前对羊膜动物所显示的那样。然而,值得注意的是,AVT和MST免疫反应纤维的相对密度和细胞数量在不同物种之间存在显著差异,即使在两栖动物的单一目中也是如此。在其他种类的脊椎动物中也有类似的观察,因此,促使我们批判性地评估关于AVT和MST在脊椎动物中枢神经系统中的特定功能的结论。Microsc.技术资源。54:125-136,2001。©2001 Wiley-Liss公司
Immunohistochemical studies during the last decade have revealed elaborate systems of vasotocinergic (AVT) and mesotocinergic (MST) neuronal elements in the brain of a variety of amphibians including anurans, urodeles, and gymnophionans. Apart from a well‐developed hypothalamo‐hypophysial system, the antibodies demonstrated the existence of extrahypothalamic AVT‐ and MST‐immunoreactive cell groups as well as extensive extrahypothalamic networks of immunoreactive fibers. The wide distribution of AVT‐ and MST‐immunoreactive fibers throughout the brains of amphibians suggests that the two neuropeptidergic systems are involved not only in hypothalamo‐hypophysial interactions, but also in a variety of other brain functions. Moreover, there is now evidence that sex‐related differences occur in amphibians as previously shown for amniotes. It should be noted, however, that substantial variation occurs in the relative densities of AVT‐ and MST‐immunoreactive fibers and number of cells between species, even within a single order of amphibians. Similar observations have been made in other classes of vertebrates and prompt us, therefore, to critically evaluate conclusions with respect to specific functions of AVT and MST in the central nervous system of vertebrates. Microsc. Res. Tech. 54:125–136, 2001. © 2001 Wiley‐Liss, Inc.
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