Daytime REM sleep in Parkinson's disease.
Daytime REM sleep in Parkinson's disease.
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DOI：
10.1016/j.parkreldis.2012.08.003
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发表时间：
2013-01
影响因子：
4.1
通讯作者：
Rye DB
中科院分区：
文献类型：
--
作者：
Bliwise DL;Trotti LM;Juncos JJ;Factor SA;Freeman A;Rye DB
先前的研究已经证明帕金森病（PD）和发作性睡病在临床和神经化学方面有相似之处。快速眼动睡眠侵入白天仍然是发作性睡病的一个主要特征，但这些侵入对帕金森病的重要性仍不清楚。在这项研究中，我们检查了 PD 患者白天维持清醒测试 (MWT) 期间的快速眼动睡眠。患者连续两天两夜都在睡眠实验室度过。白天，我们采用了改进的 MWT 程序，将每次白天小睡机会（每天 4 次）延长至 40 分钟，无论患者是否能够入睡或睡了多少时间。我们检查了每个小睡机会是否存在快速眼动睡眠和入睡时间。研究的 63 名 PD 患者中，有 11 名患者在其日间 MWT 中表现出 2 次或以上 REM 发作，10 名患者表现出 1 次 REM 发作。夜间睡眠特征和睡眠障碍与白天快速眼动睡眠的存在无关，然而，白天快速眼动睡眠的患者在白天比没有快速眼动睡眠的患者明显更困。人口统计学和临床变量，包括统一帕金森病评定量表运动评分和左旋多巴剂量当量，与快速眼动睡眠的存在无关。相当大比例的帕金森病患者在日间小睡测试中表现出快速眼动睡眠和日间睡眠倾向。这些数据证实了发作性睡病和帕金森病之间快速眼动睡眠的相似性，或许表明下丘脑分泌素缺乏症存在类似的神经退行性疾病。
Previous studies have demonstrated both clinical and neurochemical similarities between Parkinson’s disease (PD) and narcolepsy. The intrusion of REM sleep into the daytime remains a cardinal feature of narcolepsy, but the importance of these intrusions in PD remains unclear. In this study we examined REM sleep during daytime Maintenance of Wakefulness Testing (MWT) in PD patients. Patients spent 2 consecutive nights and days in the sleep laboratory. During the daytime, we employed a modified MWT procedure in which each daytime nap opportunity (4 per day) was extended to 40 minutes, regardless of whether the patient was able to sleep or how much the patient slept. We examined each nap opportunity for the presence of REM sleep and time to fall asleep. Eleven of 63 PD patients studied showed 2 or more REM episodes and 10 showed 1 REM episode on their daytime MWTs. Nocturnal sleep characteristics and sleep disorders were unrelated to the presence of daytime REM sleep, however, patients with daytime REM were significantly sleepier during the daytime than those patients without REM. Demographic and clinical variables, including Unified Parkinson’s Disease Rating Scale motor scores and levodopa dose equivalents, were unrelated to the presence of REM sleep. A sizeable proportion of PD patients demonstrated REM sleep and daytime sleep tendency during daytime nap testing. These data confirm similarities in REM intrusions between narcolepsy and PD, perhaps suggesting parallel neurodegenerative conditions of hypocretin deficiency.
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影响因子：
8.6
作者：
Bliwise, Donald L.;Trotti, Lynn Marie;Wilson, Anthony G.;Greer, Sophia A.;Wood-Siverio, Cathy;Juncos, Jorge J.;Factor, Stewart A.;Freeman, Alan;Rye, David B.
通讯作者：
Rye, David B.
影响因子：
9.9
作者：
Drouot, X;Moutereau, S;d'Ortho, MP
通讯作者：
d'Ortho, MP
影响因子：
8.6
作者：
Möller, JC;Rethfeldt, M;Oertel, WH
通讯作者：
Oertel, WH
影响因子：
8.6
作者：
Goetz, CG;Poewe, W;Seidl, L
通讯作者：
Seidl, L
影响因子：
6
作者：
Baumann, C;Ferini-Strambi, L;Bassetti, CL
通讯作者：
Bassetti, CL