Dissociable genetic contributions to error processing: a multimodal neuroimaging study.
Dissociable genetic contributions to error processing: a multimodal neuroimaging study.
复制标题
DOI：
10.1371/journal.pone.0101784
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Manoach DS
中科院分区：
文献类型：
--
作者：
Agam Y;Vangel M;Roffman JL;Gallagher PJ;Chaponis J;Haddad S;Goff DC;Greenberg JL;Wilhelm S;Smoller JW;Manoach DS
神经影像学研究可靠地确定了两个错误的标志：错误相关负波（ERN），事件相关电位，和功能性MRI激活的背侧前扣带皮层（dACC）。虽然理论上反映了相同的神经过程，但最近的证据表明，ERN来自后扣带皮层而不是dACC。在这里，我们测试了这两个错误标记也具有不同遗传介导的假设。我们测量了92名健康个体和诊断为精神分裂症、强迫症或自闭症谱系障碍的个体的样本中的两个错误标记。参与者在功能性MRI期间执行相同的任务，并同时获得脑磁图和脑电图。我们研究了两个单核苷酸多态性对错误标记的介导作用：多巴胺D4受体（DRD 4）C-521 T（rs 1800955），它与ERN和亚甲基四氢叶酸还原酶（MTHFR）C677 T（rs 1801133）相关，它与错误相关的dACC激活相关。然后，我们比较了每个多态性对两个错误标记的影响，作为一个双变量响应建模。我们重复了我们以前的报告，在精神分裂症和强迫症组的健康参与者中，ERN的后扣带回来源。基因型对错误标记的影响在诊断组之间没有显著差异。DRD 4 C-521 T等位基因负荷对ERN振幅有显著线性影响，但对dACC激活无显著线性影响，且差异显著。MTHFR C677 T等位基因负荷对dACC激活有显著线性影响，但对ERN振幅无显著影响，但对两个错误标记的影响差异不显著。 DRD 4 C-521 T，而不是MTHFR C677 T，对两个典型错误标记具有显著的差异效应。连同ERN和错误相关的dACC激活之间的解剖分离，这些发现表明，这些错误标记物具有不同的神经和遗传介导。
Neuroimaging studies reliably identify two markers of error commission: the error-related negativity (ERN), an event-related potential, and functional MRI activation of the dorsal anterior cingulate cortex (dACC). While theorized to reflect the same neural process, recent evidence suggests that the ERN arises from the posterior cingulate cortex not the dACC. Here, we tested the hypothesis that these two error markers also have different genetic mediation. We measured both error markers in a sample of 92 comprised of healthy individuals and those with diagnoses of schizophrenia, obsessive-compulsive disorder or autism spectrum disorder. Participants performed the same task during functional MRI and simultaneously acquired magnetoencephalography and electroencephalography. We examined the mediation of the error markers by two single nucleotide polymorphisms: dopamine D4 receptor (DRD4) C-521T (rs1800955), which has been associated with the ERN and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133), which has been associated with error-related dACC activation. We then compared the effects of each polymorphism on the two error markers modeled as a bivariate response. We replicated our previous report of a posterior cingulate source of the ERN in healthy participants in the schizophrenia and obsessive-compulsive disorder groups. The effect of genotype on error markers did not differ significantly by diagnostic group. DRD4 C-521T allele load had a significant linear effect on ERN amplitude, but not on dACC activation, and this difference was significant. MTHFR C677T allele load had a significant linear effect on dACC activation but not ERN amplitude, but the difference in effects on the two error markers was not significant. DRD4 C-521T, but not MTHFR C677T, had a significant differential effect on two canonical error markers. Together with the anatomical dissociation between the ERN and error-related dACC activation, these findings suggest that these error markers have different neural and genetic mediation.
登录
查看更多内容
影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
2.9
作者：
de Bruijn, Ellen R. A.;Sabbe, Bernard G. C.;Verkes, Robbert J.
通讯作者：
Verkes, Robbert J.
影响因子：
3.4
作者：
de Bruijn, ERA;Hulstijn, W;Sabbe, BGC
通讯作者：
Sabbe, BGC
DOI：
10.1073/pnas.062066299
发表时间：
2002-04-16
影响因子：
11.1
作者：
Friso, S;Choi, SW;Selhub, J
通讯作者：
Selhub, J