Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia.
Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia.
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DOI：
10.4161/gmic.28572
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发表时间：
2014-05
期刊：
影响因子：
12.2
通讯作者：
Honda K
中科院分区：
文献类型：
--
作者：
Narushima S;Sugiura Y;Oshima K;Atarashi K;Hattori M;Suematsu M;Honda K
肠道微生物区系在宿主免疫系统的发育中起着重要作用。我们先前已经证明，从常规饲养的小鼠中分离的46株共生梭状芽孢杆菌可以诱导小鼠结肠固有层中CD4+Foxp3+调节性T(Treg)细胞的聚集。随后，我们成功地从健康人的粪便样本中分离和筛选出17株梭状芽胞杆菌，该菌株能够显著增加定植的啮齿动物的结肠Treg细胞的数量和功能，从而缓解实验性变态反应性腹泻和结肠炎的症状。在这里，我们描述了17株人源性梭状芽胞杆菌对抗生素的敏感性以及产生短链脂肪酸和其他代谢物的能力，并讨论了它们作为生物疗法纠正生物失调和治疗免疫性炎症性疾病的潜力。
The gut microbiota plays important roles in the development of the host immune system. We have previously shown that a combination of 46 strains of commensal Clostridia isolated from conventionally reared mice can induce the accumulation of CD4+Foxp3+ regulatory T (Treg) cells in the mouse colonic lamina propria. Subsequently, we succeeded in isolating and selecting 17 strains of Clostridia from a healthy human fecal sample that can significantly increase the number and function of colonic Treg cells in colonized rodents, thereby attenuating symptoms of experimental allergic diarrhea and colitis. Here we characterize each of the 17 strains of human-derived Clostridia in terms of sensitivity to antibiotics and ability to produce short chain fatty acids and other metabolites, and discuss their potential as biotherapeutics to correct dysbiosis and treat immune-inflammatory diseases.
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影响因子：
3.7
作者：
Shimada Y;Kinoshita M;Harada K;Mizutani M;Masahata K;Kayama H;Takeda K
通讯作者：
Takeda K
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
32.4
作者：
Singh N;Gurav A;Sivaprakasam S;Brady E;Padia R;Shi H;Thangaraju M;Prasad PD;Manicassamy S;Munn DH;Lee JR;Offermanns S;Ganapathy V
通讯作者：
Ganapathy V
影响因子：
3.1
作者：
Reeves, Angela E.;Koenigsknecht, Mark J.;Young, Vincent B.
通讯作者：
Young, Vincent B.
影响因子：
2.4
作者：
ITOH, K;MITSUOKA, T
通讯作者：
MITSUOKA, T