Two unique human decidual macrophage populations.
Two unique human decidual macrophage populations.
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DOI：
10.4049/jimmunol.1003153
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发表时间：
2011-02-15
期刊：
影响因子：
--
通讯作者：
Strominger JL
中科院分区：
文献类型：
--
作者：
Houser BL;Tilburgs T;Hill J;Nicotra ML;Strominger JL
在母胎界面发生了几个重要事件，包括母胎耐受的产生、子宫平滑肌及其螺旋动脉和腺体的重塑以及胎盘的构建。胎儿来源的绒毛外滋养层细胞与母体蜕膜白细胞直接接触。巨噬细胞占该界面白细胞的约20%。在这项研究中，两个不同的亚群的CD 14+蜕膜巨噬细胞（dM的）被发现存在于第一个三个月的蜕膜组织，CD 11 cHI和CD 11 cLO。基因表达谱芯片分析显示，379个探针在这两个群体之间差异表达。两个子集的分析揭示了几个集群的共调节基因，这些子集在组织重塑，生长和发育的不同功能。CD 11 cHI dM β表达与脂质代谢和炎症相关的基因，而CD 11 cLO dM β表达与细胞外基质形成、肌肉调节和组织生长相关的基因。CD 11 cHI dM β在处理蛋白Ag的能力方面也不同于CD 11 cLO dM β，并且可能是蜕膜中的主要APC。此外，这些群体各自分泌促炎和抗炎细胞因子，这可能有助于建立胎儿-母体耐受性的平衡。因此，它们不符合传统的M1/M2分类。
Several important events occur at the maternal–fetal interface, including generation of maternal–fetal tolerance, remodeling of the uterine smooth muscle and its spiral arteries and glands, and placental construction. Fetal-derived extravillous trophoblasts come in direct contact with maternal decidual leukocytes. Macrophages represent ~20% of the leukocytes at this interface. In this study, two distinct subsets of CD14+ decidual macrophages (dMϕs) are found to be present in first-trimester decidual tissue, CD11cHI and CD11cLO. Gene expression analysis by RNA microarray revealed that 379 probes were differentially expressed between these two populations. Analysis of the two subsets revealed several clusters of coregulated genes that suggest distinct functions for these subsets in tissue remodeling, growth, and development. CD11cHI dMϕs express genes associated with lipid metabolism and inflammation, whereas CD11cLO dMϕs express genes associated with extracellular matrix formation, muscle regulation, and tissue growth. The CD11cHI dMϕs also differ from CD11cLO dMϕs in their ability to process protein Ag and are likely to be the major APCs in the decidua. Moreover, these populations each secrete both proinflammatory and anti-inflammatory cytokines that may contribute to the balance that establishes fetal–maternal tolerance. Thus, they do not fit the conventional M1/M2 categorization.
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影响因子：
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